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Fruit flies made by experiments
Researchers at the Sanford Burnham Preys Discovery Medical Center (SBP) in the United States have identified a genetic marker and genes responsible for the hereditary heart disease of the child due to genetic obesity, which subsequently allows for intervention. to protect them, in a study published Jan. 14. Nature Communications Journal.
To achieve this result, the research team used Drosophila: about 75% of the human disease genes contain isotopes that can be detected in the fruit fly, and successive generations in this insect (about two weeks between each generation). make them fit for research, according to Dr. Rolf Bauder, lead author of the study for Al Ain News.
During the study, scientists fed fruit flies for 5 days with a diet rich in coconut oil. The flies then became obese and suffered a build up of fat in the heart cells, resulting in an irregular heartbeat and a second and third generation, although they were exposed to a normal diet.
By comparing these generations with generations of flies born to parents with a natural diet, scientists have identified a genetic hereditary marker (H3K27me3) whose reduction would reduce the number of fruit flies to protect future generations from cardiac dysfunction.
The researchers also identified two genes involved in metabolism (bmm and PGC-1). "Our results reveal a hereditary mechanism behind heart failure fueled by a high-fat diet as well as a genetic factor and genetic targets that can be explored to protect individuals from the effects of poor diet." for their parents or grandparents, "says Dr. Bauder.
"It's still too early, more studies are needed on flies and mice before people move," said Dr. Bauder. "This study is the first innovative effort in this direction."
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