For the first time: scientists succeed in developing a vaccine that is not "antibodies"

Researchers at the University of Nebraska have developed an effective vaccine against the Zika virus, which works well by fighting the virus without producing antibodies.

Ordinary vaccines act by forming a group of antibodies in the body, injecting humans with pathogens such as bacteria and microbes. The immune system produces antibodies that fight these factors, but the The use of the vaccine itself poses a direct threat to the immune system. Intentionally injected into the body.

Despite the safety, efficacy, and efficacy of vaccines, researchers have been trying for decades to develop vaccines other than antibodies. Researchers at the University of Nebraska have succeeded, which will have a considerable future impact on the field of vaccine science.

Eric Weaver, the first researcher in the study, badociate professor of neuroscience at the University of Nebraska, describes this initiative as "a great victory not only against Zika, but also against all diseases."

Many reports show that zica-resistant antibodies can increase the infection of another fever virus, for example dengue fever. This is what is called "promoting antibodies based on another disease". Vaccines form antibodies that may contribute to the transmission of another disease, and thus, the crisis has remained an obstacle to the development of vaccines for the "Zika" virus.

"Vaccination against Zika through vaccines further aggravates the body's response to other viruses," says Weaver in a press release. "Immune globulin-induced antibodies" can cause dengue death. .

In the study published today in Scientific Reports, researchers made genetic modifications to a version of a virus, usually responsible for a mild illness such as the common cold, and used it as an effective vector of 'a type of vaccine used to fight the Zika virus.

In the beginning, the researchers injected the cold virus into the experimental mice and then waited for confirmation of the formation of antibodies, before injecting the Zika vaccine carrying virus into the same mice and because the immune system of these mice had a powerful "memory". , No new antibodies ever formed.

Further studies are needed to determine if the virus is safe for humans, but the principal investigator, Eric Weaver, says that the discovery of this mechanism will allow us to apply it to various strategies of the vaccine industry for other diseases, Total safety in the case of Zika virus.