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Dr. Yousef Mahmoud Salama, a graduate student at An-Najah National University, recently participated in a team of researchers from the Institute of Medical Sciences of the University of Tokyo, Japan, in order to develop a new mechanism for identifying the proteins and receptors present in the cancer cells responsible for melanoma.
Dr. Salama was the first author of the research paper and a member of the research team of the University of Tokyo discovered the research idea.
Melanoma accounts for about 1% of skin cancers, but is responsible for the vast majority of deaths from this type of cancer, according to the American Cancer Society.
Melanoma tumors develop more in relation to others, where they are probably due to interactions between a pair of molecules.By a process called metastasis, tumors reach the lungs, liver, spleen and other organs from the body.
According to experiments conducted on mice and human cells, a large tumor is formed during the injection of this type of cancer cells, causing the death of injected mice in less than a month. of the research team are likely to restore a type of cancer treatment that was abandoned Previously, the results suggest that a molecule is already badociated with obesity and dementia as a possible cause of malignancy, or the spread of cancer cells to other parts of the body.
The Medical Group of the University of Tokyo led by Associate Professor Betty Hessig has studied protein (plasminogen activator) and abbreviated tPA for more than a decade. (LRP1) In these experiments, the team discovered that inhibition of the badociated protein or receptors leads to a significant reduction in the spread of cancer cells.
Mr. Salama graduated from the Department of Biotechnology at the Faculty of Science of An-Najah University in 2009. He has worked as a research and teaching badistant at the university before starting work. graduating in 2012 and completing his graduate studies in Japan.
In Japan, Dr. Salama has been active in cancer and stem cells before becoming one of the best researchers in this field, not only at the Japanese level, but also at the global level.
"A better understanding of the specific interactions between PRL and TPA gives us hope that it will lead to a cure for cancers resulting from TPA and activity, while maintaining the ability to maintain normal processes." and important protein protease in the body, "said Dr. Salama.
Dr. Salama also suggests that gene therapy can be badociated with cancer immunotherapy when the mechanism used by cancer is targeted by proteins, allowing the immune system to function and prevent the spread of cancer in the body.
Speaking on behalf of the research team, Dr. Salameh said, "When we tested mice using genetically modified cancer cells by suppressing the TPA, LRP1 protein-producing genes, we found a Remarkable stopping of cancer cell proliferation that has not been injected with any type of cancer cells. "
This new discovery is a giant leap forward in the search for a new mechanism to reduce the spread of this high-risk, deadly cancer by discovering the positive relationship between TPA and LRP1 proteins, which could put us at the threshold of a new therapeutic age based on the manufacture of drugs and medicines. And new antiretroviral agents that can primarily target tumor mutations of tumors.
The new discovery was published in a well-known scientific journal on molecular genetics (THE FASEB JOURNAL). Dr. Salama was named first editor and the name of the An-Najah University was named.
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