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Scientists have been able to transplant for the first time into the laboratory "ideal" human blood vessels, a breakthrough that can have a major impact on research in the field of vascular disease and diabetes.
Joseph Binger, director of the Institute of Life Sciences of the University of British Columbia, said the ability to build human blood vessels as organic stem cells was a major change in the rules of the game.
"Each member of our body is connected to the circulatory system.This may enable researchers to identify the causes and methods of treatment of various vascular diseases, including Alzheimer's disease, heart disease, wound healing, wounds, stroke, cancer and, of course, diabetes. "
Binger and his colleagues have developed a three-dimensional method of vascular transplantation in a petri dish.
Implantation is in the form of a three-dimensional structure derived from organ-simulating stem cells, and can be used to study aspects of this limb in a Petri dish.
When researchers developed an improved blood vessel structure in mice, they found that it had evolved into fully functioning human blood vessels, including arteries and capillaries.
This discovery shows that it is possible to conceive the structure of blood vessels from human stem cells in a Petri dish, in addition to the growth of the human functional vascular system in other species.
The technology developed, described in the journal Natural, revealed new ways to prevent possible changes in blood vessels, a leading cause of death from diabetes.
The researchers exposed the organic blood vessels of "the environment of diabetes" and observed a significant expansion of the basement membrane, "remarkably similar" to the vascular damage seen in diabetics.
They then searched for chemical compounds that could mask the thickness of blood vessel walls and found that none of the current antidiabetic drugs had a positive effect on blood vessel defects.
However, the researchers discovered that an inhibitor of the – secretase, an enzyme of the body, prevented the intensification of blood vessel walls, suggesting that it could be useful in the treatment of diabetes.
The researchers say the findings could allow them to identify the underlying causes of vascular disease and possibly develop and test new treatments for diabetics.
Source: Daily Mail
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