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A modified form of botulinum toxin popularly known as botox, provides relief of chronic pain without adverse effects, according to a study published today in the journal Science. Translational Medicine
Researchers at University College London (UCL) deconstructed the botulinum molecule and reassembled it with an opioid type, which resulted in a compound that reduced the signals pain in the spinal cord . of the mouse.
"Injected into the spine, relieves chronic pain, such as that caused by nerve injury, and avoids the adverse events of tolerance and dependence often associated with the repeated use of opioid drugs, "says lead author Steve Hunt of UCL
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According to the researcher, this new mix it does not have. does not affect muscles as the botulinum toxin used to reduce wrinkles, but it blocks nerve pain up to four months without affecting the normal responses to pain. [19659002] considered that this product "could revolutionize the way chronic pain is treated" when it is transferred to the clinic, as this would eliminate the need for daily intake of opioids.
Pain c "moderate to severe" intensity is widespread and affects 7.8 million people in the UK and 19% of adult Europeans.
Opioids such as morphine and fentanyl are considered the usual mechanism for pain relief. but there is little evidence that its use is effective in the long-term in the treatment of chronic pain .
This is because the body develops over time a tolerance to the repeated use of these drugs.
Other d The points against the use of opioids is that they can activate the areas of the brain that cause addiction. More than 2 million people in the United States, for example, have a disorder of opioid use .
Read also: In Mexico, 27% of the population suffers from chronic pain
trying to solve this problem, the team led by Hunt developed a molecular system that allows the creation of long analgesics duration without the side effects of opioids
Over a five-year period, they used 200 mice to simulate the early stages of neuropathic pain and human inflammatory and were treated with a single injection of the mixture , another modification of the botulinum molecule or morphine.
The behavior of the mice was monitored for their response to pain and the locations and binding properties of botulinum compounds .
"We were impressed to see that a small injection of the mixture developed was their enough to stop the chronic pain caused by inflammation for at least a month," said Maria Maiaru, another of researchers from the UCL team.
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