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The experiment, in the Netherlands, sought to show that the popular drug, which improves circulation, might help in cases where fetal growth is severely compromised.
An experiment with pregnant women in the Netherlands seems to have gone wrong. According to The Guardian, a group of Dutch researchers suspended a clinical trial due to the deaths of 11 babies from lung disease after their mothers were treated with sildenafil (Viagra) during pregnancy.
Mothers were participating in a clinical trial to evaluate the safety and efficacy of the drug in infants with "severe fetal growth restriction" who were at significant risk of being born dead or alive. die after birth.
Half of the 183 mothers in the trial had been treated with sildenafil, while the other half had received a placebo. By the time they received the drug, the mothers did not know what treatment they were receiving. This procedure is standard in clinical trial protocols.
The intention was that the drug, which improves the function of the blood vessels, will increase the function of the placenta, thus improving the growth of the fetus. However, the researchers found that the drug caused babies a kind of hypertension in the lungs: a disease in the blood vessels of the lungs that increased the risk of death after birth.
183 women participated in the clinical trial in 11 cities in the Netherlands since 2015. Ninety-three women were treated with this drug and 90 were treated with placebo.
Painful results
Of the 93 women were treated with the drug, 19 babies died (11 of them due to a lung disorder). Six other babies were born with the lung disorder and survived. In comparison, nine babies born to women treated with placebo died, but none of them suffered from a lung disorder. At the same time, 3 babies with lung disorders were born to women treated with placebo, and all survived.
"We wanted to show that it's an effective way to promote baby's growth, but it's the opposite that has happened. The last thing you want is to hurt patients, "said Wessel Ganzevoort, a gynecologist from the Medical Center of the University of Amsterdam, to the Dutch newspaper De Volkskrant
to treat women whose babies do not seem to be well developed, but previous studies in the United Kingdom and New Zealand have shown that no single factor has been able to prove that the drug was to stabilize the weight of newborns.
At the moment, Pfizer, the company The manufacturer of Viagra said that they did not participate in medical tests. "The research is a study initiated by a Researcher and Pfizer has no involvement in the trial, "said Dervila Keane at CNN, Pfizer spokesperson.
Pregnancy is the most delicate stage of human growth. last year, he discovered that a food n high fat during pregnancy was associated with mental disorders and that in April of this year it was discovered that infections during pregnancy have consequences on the cognitive development of the baby
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