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Metabolism has two types of adipose tissue : a white adipose that stores extra calories and another brown or brown, a kind of fat that burns them to produce heat. Now, a new study reveals the mechanism by which the latter is activated, which could be used to control obesity.
The research, led by scientists from the Spanish National Center for Cardiovascular Research (CNIC), is published in "Plos Biology" and, according to their authors, in addition to having potential clinical implications for the treatment of cancer. Obesity He also has for diseases related to him, such as diabetes.
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Obesity is an epidemic problem and it is estimated that about 2.2 billion people are overweight or obese in the world . In recent years, researchers are focusing on the thorough study of the functioning of adipose tissue especially brown fat, to better understand how it can combat the problems caused by obesity, has declared the CNIC. In a statement
And that is, one of the lines of research to solve this problem would be handling this "good" fat that burns energy to maintain adequate body temperature and promotes the body to burn energy
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Guadalupe Sabio and his team have been working for some time at the CNIC to understand the mechanisms which are needed to activate this brown fat and thus eliminate excess fat in obese people.
Most fats that are in humans are white – brown only at the jugular – hence the int You are trying to convert white to Therefore, in this work, experiments were performed with both white fat in human samples and with brown fat in mice. In both, the p38 alpha protein has been studied, Guadalupe Sabio, one of the authors of the study, told EFE
Thus, in more than 150 samples of human adipose tissue, there was found that this protein obese, suggesting that for this reason, no other protein the UCP1, is regulated to activate brown fat.
However, in investigations of genetically modified mice and with brown fat, He saw that the absence of p38 alpha causes the opposite, despite a fatty diet: the lack of this protein in these animals activate the brown fat and also protect against diabetes and fatty liver.
according to this research, the protein p38 alpha controls the activation of another protein of the same family, p38 delta, which would be responsible for the regulation of temperature: when mice are subjected to low temperatures, p38 delta ac tiva, increasing the activity of brown fat.
Missing alpha p38 mice, he added, have overactivated p38 delta, which gives them protection against obesity. EFE
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