[ad_1]
A method to treat cancer, HIV and falcemia
LONDON (EFE) .- Scientists in the UK have discovered that Crispr / Cas9 gene editing technology can cause more damage to the cells that it was what we believed until now, according to a study published yesterday by the journal Nature.
Research developed by the Wellcome Sanger Institute warns of some consequences of using this revolutionary "cut-stick" technique, which allows experts to remove and replace sections of DNA in the cells of any organism, including the human.
Scientists also reveal that standard tests designed to detect changes in DNA are not able to predict these genetic damage, so they recommend caution and propose specific tests to assess the validity of genetic therapies .
In addition to its widespread use in scientific research, Crispr / Cas9 has resulted in positive results in the design of genome editing therapies to treat cancer, VHI or falcemia.
However, remember, previous studies have not detected the existence of unexpected mutations in the DNA in the specific field of genome editing. genome made with Crispr / Cas9
Therefore, Wellcome Sanger experts undertook a large systematic study in mice and humans and found that Crispr / Cas9 often causes extensive mutations, although they are localized at a certain level.
As a result, many genetic cells have undergone significant rearrangements, with "deletions" and "insertions" of DNA, which can cause the activation or deactivation of certain key genes. 19659003] "This is the first systematic analysis of the unexpected effects caused by editing with Crispr / Cas9 in cells that are therapeutically relevant, and we discovered that the changes made to the DNA has been underestimated until now, "said one of the authors, Allan Bradley, in a statement
.
Study More details
Crispr technology / Cas9 has been used for several treatments of various diseases
Alternatives
This work raises questions about the use of Crispr / Cas9 and should pave the way for the scientific community "
Evident
"In my early experiments, I used Crispr / Cas9 as a tool to study genetic activity, however, it became clear that something unexpected was happening," Michael contributed. Kosicki, the expert in charge of this looking for you
[ad_2]
Source link
