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MEXICO (Notimex) .- Clinically healthy miners living in Mexico City have higher concentrations of glucose and leptin fasting, resistance to l & # 39; insulin and deficiency vitamin D, associated with the exposure of environmental pollutants such as gasoline, diesel and oils, which increases the risk of suffering L & # 39; obesity and Type 2 diabetes.
Lilian Calderón Garcidueñas, researcher University of the Valley of Mexico (UVM), reported the above when he reported on the results of his research in which he analyzed various factors in clinically healthy people of normal weight, with an average age of 11 years.
He added that it was a study enrolling in the line of research conducted for 15 years on the association of environmental pollution with the neurodegenerative diseases and in which they discovered a series of synergistic factors in the interaction between the brain, the brain and the environment. peripheral nervous system, the gastrointestinal tract and the environment.
He noted that air pollutants are common environmental contaminants, such as molds and fine particles on the outside and inside (PM2.5).
How they invade us
According to the university specialist, nanoparticles enter the brain through the nose directly through the nose and are swallowed in the gastrointestinal tract, where they enter the systemic circulation or reach the brain by axonal transport of nerves such as the trigeminal and the vagus.
The nanoparticles use the red blood cells to reach all the organs of the individual, including of course the brain, where they adhere to the endothelium, pass to the other side of the blood-brain barrier and even pass the membranes to the level cell, hence the need to extend the investigation to different bodies.
In a statement from the UVM, Calderón Garcidueñas said that according to his various studies, environmental contaminants had a negative impact on children's health.
The damage may be caused by impaired immunity, delayed psychomotor development, hypertension, insulin dysregulation, reduced lung function, premature birth, cognitive and olfactory abnormalities, volumetric changes of the white matter, systemic inflammation, neuroinflammation and features of Alzheimer's disease.
findings
Among the highlights of this study, 87% of participating children, who had a normal "non-obese" body mass index, had high fasting leptin concentrations, higher blood glucose levels, as well as a deficiency. . of vitamin D.
The researcher commented that obese children were predisposed to diabetes and that they were linked to high levels of leptin and the soluble leptin receptor.
In this research, it is shown that non-obese children suffer from hyperleptinemia, as neuroinflammation and endothelial lesions probably contribute to alterations in the transport of leptin to strategic brain sites.
To complicate the scenario, these children also have a marked deficiency of vitamin D, which is important because of the known metabolic links and dementia.
Opportunity
The neuropathologist and neurotoxicologist said that today, we had a 50-year window of opportunity between the time children growing up in contaminated urban environments experience the adverse metabolic effects described in this research and study. the day they develop dementia.
Current metabolic data that affects the health of millions of children in urban areas require immediate action if we focus on identifying and mitigating the environmental factors that influence obesity, cardio-metabolic diseases, diabetes mellitus and Alzheimer's disease.
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