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Jewish Link Mexico and Israel – Scientists from Tel Aviv University invented the first fully customized tissue implant, designed from the patient's cells..
The new technology makes it possible to design any type of tissue implant, for the spinal cord, the heart or the brain, from a small biopsy of adipose tissue.
"We have succeeded in creating a custom hydrogel from adipose tissue biopsy materials in different cell types to design cardiac, medullary, cortical and other implants to treat different diseases," says Professor Tal Dvir of the Center for Nanoscience . and nanotechnology of Tel Aviv University and the Sagol Center for Regenerative Biotechnology.
"Since the cells and material used come from the patient, the implant does not cause an immune response, which ensures proper regeneration of the defective organ," he says.
The study was conducted by Dvir, Reuven Edri, postdoctoral researcher and PhD students Nadav Noor and Idan Gal, in collaboration with professors Dan Peer and Irit Gat Viks of UTA's department of cell research and immunology and the Professor Lior Heller. Assaf HaRofeh Medical Center in Israel, recently published in Advanced Materials magazine.
In tissue engineering for regenerative medicine, the cells are isolated from the patient and cultured in biomaterials for introduction into functional tissues. These biomaterials can be synthetic or natural, derived from plants or animals.
This transplant can provoke an immune response that results in the rejection of the implanted tissue, endangering the health of the patient.
"Thanks to our technology, we can design any type of tissue and, after transplantation, effectively regenerate any sick or injured organ: an infarcted heart, a brain after a trauma or a Parkinson's disease, a spinal cord after an injury" Said Dvir.
"In addition, we can design adipogenic implants [tejido graso] for reconstructive or aesthetic surgeries that are not rejected by the body ".
Scientists extracted a small biopsy of patients' adipose tissue and separated their cellular and extracellular materials. The cells have been reprogrammed to become pluripotent stem cells, capable of producing cells from the three fundamental layers of the body, so that they can produce all the cells or tissues that the body needs to repair itself, the extracellular material has been transformed to become a custom hydrogel.
After associating the obtained stem cells with the hydrogel, the scientists successfully designed the custom tissue samples and tested the immune response of the patients.
Currently, they perform tests with these implants for the regeneration of an injured spinal cord and an infarcted heart. They also began to study the operation of custom implants for the treatment of Parkinson's disease in animal models.
The researchers plan to regenerate other organs, including the intestines and eyes, using the cells of their patients.
"We believe that fully customized tissue implant engineering technology will enable us to regenerate any organ with a minimal risk of immune response," concluded Dvir.
Source: ISRAEL21c / Reproduction authorized with the mention: © EnlaceJudíoMéxico
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