[ad_1]
Find advantages in the use of an anti-inflammatory drug
MEXICO (Notimex) .- A study conducted at the Institute of Medical Research Hospital del Mar (IMIM), in Spain reveals that an anti-inflammatory drug used in advanced stages of the disease Chronic obstructive pulmonary disease (COPD) has beneficial effects on weight loss and muscle mass (cachexia).
Cachexia causes deterioration of the whole body and particularly affects skeletal muscles, leading to muscle atrophy and even pulmonologist Esther Barreiro points out that in the early periods of COPD, attempts are made to reduce cachexia with Physical rehabilitation treatments, while in advanced stages, it is very complicated to reverse it and there is no pharmacological therapy.
For this reason, they were interested in studying the molecular mechanisms involved in the disease process, which they were treated with primary cultures and live cells from patients with advanced COPD and samples muscles of healthy people.
Dr. Barreiro adds that the anti-inflammatory drug Roflumilast has been administered at different doses and hours to stem cells. biological mechanisms, such as decreasing levels of oxidative stress, triggering protein degradation, and increasing regulatory transcription factors that promote protein synthesis.
Specifies that all the mechanisms mentioned allow control of exaggerated loss of mass
Dr. Barreiro points out that the results in patients show an improvement in the metabolic parameters of muscle cells, which means that the stem cells that were foreign to the muscle of COPD patients are very similar to "satellite cells" obtained from "It is shown that these cells are very well preserved despite the poor condition of the muscle in vivo in the patient, which could open the door to future treatments using the conservation factor of these cells, "he says.
"Once the therapeutic potential of Roflumilast is confirmed at the cellular level, it would be interesting to study directly in patients who receive treatment to establish exactly the benefit that this implies for the disease". COPD is one of the most prevalent and deadly diseases in the world.
EPOC Details
People with this problem have reduced their physical capacity
Consequence
Due to this situation, patients lose their physical abilities, which leads to a loss of muscle mass.
Medication
Respirologist Esther Barreiro explains that the oral anti-inflammatory drug is given as an injection to supplement the inhaled bronchodilator method
[ad_2]
Source link
