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The largest coordinated research effort to study biological and non-biological factors associated with aggressive prostate cancer in African-American men has begun. The $ 26.5-million study called RESPOND, or Prostate Cancer Research in Men of African Descent: Defining the Roles of Genetics, Tumor Markers, and Stress social. He will study the environmental and genetic factors associated with the aggressiveness of prostate cancer in African American men to better understand why they suffer disproportionately from an aggressive disease – a disease that grows and spreads quickly – compared to men from other racial and ethnic groups. ] RESPOND is supported by the National Cancer Institute (NCI) and the National Institute on Minority Health and Disparities in Health (NIMHD), both parts of the National Institutes of Health, as well as by the Prostate Cancer Foundation (PCF). "Understanding why African American men are more likely to be diagnosed with aggressive prostate cancer than men from other racial and ethnic groups is a critical and unanswered question within the framework of the US. Moonshot Cancer Initiative 21st Century Cancer Cures
"Ned Sharpless, NCI Director" This extensive collaborative study can help the cancer research community better understand and eliminate these disparities. "
African men and women Americans have about 15% chance of developing prostate cancer their life, compared to about 10% chance for white men, and African-American men are more likely to be diagnosed with an aggressive illness. Plus, the risk of dying from prostate cancer in African-American men is about 4% versus about 2% in white men.With the RESPOND study, researchers seek to learn more about the reasons for these disparities.
"This study, which combines state-of-the-art molecular approaches with social and environmental science, will help unravel the complex interactions of biological, behavioral and environmental factors that contribute to the excess burden of prostate cancer and lower results in African-American men, allowing the development of tailor-made approaches for prevention, diagnosis and treatment in this population, "said NIMHD director Eliseo Pérez-Stable, MD
researchers aim to enroll 10,000 African-American men with prostate cancer.Study.Participants will be primarily identified through the NCI Surveillance and Epidemiology and Final Results Program (SEER) and the National Program. The Centers for Disease Control and Prevention's cancer registries are also based on years of research collaboration. involving researchers from the African Ancestry Prostate Cancer (AAPC) consortium. These researchers will provide additional information and samples from 10,000 African American men with prostate cancer. In accordance with NIH's data-sharing policies, and with appropriate informed consent, anonymized data and samples collected as part of this research will be made available to the scientific community, assisting with future research.
will examine the possible associations between aggressive disease and exposure to environmental or neighborhood stressors such as discrimination, early adversity, and segregation. They will also study DNA samples and tumors to identify genetic variants associated with aggressive prostate cancer. Once researchers have identified the genetic changes associated with aggressive prostate cancer, they will study how the social environment interacts with these genetic changes.
"Previous research on disparities in prostate cancer has separately studied social and genetic factors. Said Damali Martin, Ph.D., program director for the study in NCI's epidemiology and genomics research program. "The ability to integrate genetic and environmental factors, including individual, neighborhood and societal factors, into one large study will allow us to better understand how all of these factors contribute to the aggressiveness of prostate cancer." . "
RESPOND, a cooperative agreement, will be led by Christopher Haiman, Sc.D., of the University of Southern California (USC) in Los Angeles, in collaboration with John Carpten, Ph.D., Ann Hamilton, Ph.D., and David Conti, Ph.D., also from USC; Scarlett Gomez, Ph.D., from the University of California, San Francisco; Tamara Lotan, MD, from Johns Hopkins University in Baltimore; and Franklin Huang, MD, Ph.D., of the Boston Dana-Farber Cancer Institute
NCI's Division of Epidemiology and Cancer Genetics will perform genotyping, and the Center for Disease Research Hereditary Johns Hopkins University's genetic component of the study. "No group in the world is more affected by prostate cancer than men of African descent and, to date, little is known about the biological reasons for these disparities. or the full impact of environmental factors, "said Jonathan W. Simons, MD, President and CEO of PCF. "We celebrate our partnership and congratulate the NIH for conducting this study, which we believe will help pave the way for breakthrough discoveries that will improve health equity for African-American men and their families."
by the National Institutes of Health. Note: Content may have changed for length and content. For more information, please contact the cited source.
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