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National Follow-up Program
The study is part of the national follow-up of the HPV vaccination program of the National Institute of Health. Since 2011, girls from different age groups between the ages of 17 and 21 have been invited to participate in the surveys. More than 40,000 girls have participated so far by submitting a urine sample.
In this study, the incidence of HPV in the urine samples of the first cohort of Grade 7 vaccine was born in 1997, with samples of girls born in 1994 and 1996 who did not show any evidence of HPV infection. have not received the offer. Samples from both groups were collected when the girls were 17 years old. In total, urine samples of nearly 18,000 girls were analyzed for 37 different types of HPV.
Significantly reduced incidence of HPV
The incidence of 37 different HPV viruses in urine samples was 19.9% in girls born in 1994 and 11, 4% in girls born in 1997.
The incidence of HPV types against which the vaccine protects (6, 11, 16 and 18) was 7.4% for girls born in 1994 and 1.4% for girls born in Canada. 1997. For the full scope of 1997, the incidence of all types of HPV was reduced overall by 42%, while the types of protected vaccines were reduced by 81% [19659003] – These results are very satisfactory.
We also compared data from unaccompanied girls born in 1994 and in a number of studies from other countries on the effect of the vaccine against HPV, "says Berit Feiring, first author of the study at the Institute of Public Health. vaccinated daughter was born in 1997. Then, the incidence of HPV types that the vaccine protects against 7.7% in unvaccinated girls while the vaccinated girls were only 0.8 %. Among unaccompanied girls born in 1997, the incidence of vaccine types was 3.5%, 54% less than that of unaccompanied girls born in 1994. [19659003] – The decline we see in girls who have not taken the vaccine is due to herd protection, Feiring says.
In the study, urine tests for girls born in 1996 were also analyzed. This cohort was not offered the seventh-stage HPV vaccine. However, the incidence of HPV has dropped in these girls as well as in girls born in 1994. Since these girls are only one year older than the first cohort vaccinated, it is natural to have a healthy pregnancy. interpret this decline as an expression of herd protection. against other types of HPV than vaccine covers
The study also shows a 68% reduction in HPV types 31, 33 and 45. These types of HPV are not included in the vaccine. This means that the vaccine also protects against other types of HPV than the vaccine, what is called cross-protection.
Reductions were also observed for several other non-vaccine HPV types, including HPV 52 (51% reduction) and HPV 58 (32% reduction). A reduction in the frequency of unvaccinated types has also been observed in unvaccinated girls and also indicates herd protection for these types.
Study Study
Approximately 20% of girls in the cohorts of 1994, 1996, and 1997 participated in a urine test. they were 17 years old. Urine tests were analyzed for HPV at the National Reference Laboratory for HPV at Akershus University Hospital. HPV vaccination data from the National Immunization Register (SYSVAK) were then linked to HPV results in order to compare results for vaccinated and unvaccinated girls. The Gardasil HPV vaccine that protects against HPV types 6, 11, 16 and 18 was used in Norway during the study period. The study is based on repeated cross-sectional studies
Full article: Feiring B, Laake I, Christiansen IK, Hansen M, Stålcrantz J, Ambur OH, Magnus P, CM Jonassen, Trogstad L Substantial Reduced prevalence of vaccine and non-vaccine HPV in vaccinated and unvaccinated girls 5 years after the implementation of the HPV vaccine in Norway . Journal of Infectious Diseases 2018; July 16, 2018
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