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University of Auckland, Auckland, New Zealand (V.S., R.J., K.P., B.W., M.H., C.G., R.P., S.M., S.W.)

University of Auckland and Middlemore Hospital, Auckland, New Zealand (A.K.)

Recognition: The authors thank the primary health care organizations, primary care physicians, nurses and affiliated patients for their contributions to this study.

The development of the PREDICT cohort is the fruit of a collaboration between epidemiologists and other clinical researchers from the University of Auckland, information technology specialists at Enigma Solutions (a private specialty company). in the information technologies that developed and maintains the PREDICT software and web server), primary health care organizations (and their primary care physicians members), non-governmental organizations (Neo Guidelines Group). New Zealand Foundation for the Heart, Diabetes New Zealand and Diabetes Auckland), several DHB and the Ministry of Health. The software platform PREDICT belongs to Enigma Publishing (PREDICT is a trademark of Enigma Solutions).

Financial aid: By project, 15/165 grant from the Health Research Council of New Zealand. Professors Jackson, Harwood, Kerr and Wells; Drs. Gray, Mehta and Poppe; and Mr. Wu receives funding from the New Zealand Health Research Council for training grants for programs, projects and clinical research for CVD research. Dr. Poppe received a Senior Hynds Fellowship from the Heart Foundation of New Zealand and Dr. Gray received a research grant from the Heart Foundation of New Zealand. Professor Wells received a Health and Quality Improvement Grant funded by the Stevenson Foundation. Apart from this research, Professors Wells and Poppe received funding from the Heart Foundation of New Zealand (Project Grants for Quality Improvement and Structural Heart Disease, respectively) and Professor Wells from Roche Diagnostics (project grant for health centers). test test).

Disclosures: Dr. Selak reports on grants from the New Zealand Health Research Council during the study. Professor Jackson reports grants from the University of Auckland in carrying out the study. Dr. Poppe mentions grants from the Health Research Council of New Zealand and the Heart Foundation of New Zealand during the study. Mr. Wu reports on grants from the New Zealand Health Research Council during the study. Professor Harwood reports on grants from the New Zealand Health Research Council during the study. Dr. Gray mentions grants from the Heart Foundation of New Zealand and the Health Research Council of New Zealand when conducting the study. Dr. Mehta reports grants from the Health Research Council of New Zealand during the study. Dr. Kerr mentions grants from the New Zealand Health Research Council during the study. Professor Wells mentions grants from the Health Research Council of New Zealand and the Stevenson Foundation during the conduct of the study, as well as grants from the Heart Foundation of New Zealand and Roche Diagnostics, outside of the submitted work. The unnamed authors here have revealed no conflict of interest. Disclosures can also be found at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M18-2808.

Disclosures of the editors: Christine Laine, MD, MPH, editor-in-chief, says his wife holds stock / asset purchase options with targeted diagnoses and therapies. Darren B. Taichman, MD, PhD, editor, says that he has no financial relationship and no interest in disclosing. Cynthia D. Mulrow, MD, MSc, Associate Editor, says she has no relationship or interest in disclosing. Jaya K. Rao, MD, MHS, Associate Editor, says she has stock / stock options at Eli Lilly and Pfizer. Catharine B. Stack, PhD, MS, Associate Editor for Statistics, says she owns shares in Proctor & Gamble, Pfizer and Johnson & Johnson. Christina C. Wee, MD, MPH, Associate Editor, reports a job at Beth Israel Deaconess Medical Center. Sankey V. Williams, MD, deputy editor, says that he has no financial relationship and no interest in disclosing. Yu-Xiao Yang, MD, MSCE, deputy editor, says that he has no financial relationship nor any interest in disclosing.

Repeatable Research Statement:Study protocol and dataset: Unavailable. Statistical code: Available from Dr. Selak (e-mail, [email protected]).

Corresponding author: Vanessa Selak, PhD, Epidemiology and Biostatistics Section, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; e-mail, [email protected]auckland.ac.nz.

Address of the current author: Professors Jackson, Harwood, Kerr and Wells; Drs. Selak, Poppe, Gray and Mehta; Mr. Wu; and Ms. Pylypchuk: University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

Author contributions: Design and Design: V. Selak, R. Jackson, S. Mehta, S. Wells.

Data Analysis and Interpretation: V. Selak, R. Jackson, K. Poppe, C. Gray, R. Pylypchuk, S. Mehta, S. Wells.

Article Writing: V. Selak, S. Wells.

Critical review of the article for important intellectual content: V. Selak, R. Jackson, K. Poppe, Gray C., R. Pylypchuk, S. Mehta, S. Wells.

Final approval of the article: V. Selak, R. Jackson, K. Poppe, B. Wu, M. Harwood, C. Gray, R. Pylypchuk, S. Mehta, A. Kerr, S. Wells.

Supply of study materials or patients: R. Jackson.

Statistical expertise: V. Selak, K. Poppe, R. Pylypchuk.

Obtaining funding: V. Selak, R. Jackson, K. Poppe, M. Harwood, S. Wells.

Administrative, technical or logistical assistance: R. Jackson, B. Wu, M. Harwood.

Data collection and assembly: V. Selak, R. Jackson, B. Wu, S. Wells.

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