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A team led by researchers from the Washington University School of Medicine in St. Louis presented experimental therapy for an inherited form of ALS or amyotrophic lateral sclerosis, also known as Lou's disease. Gehrig, the same disease as the famous physicist Stephen Hawking.
The new treatment increased life expectancy and reversed signs of neuromuscular and neurodegenerative disorders in mice and rats, writes descopera.ro, which cites Medical Xpress. The study, published July 16 in the Journal of Clinical Investigation, led to the launch of clinical trials to determine whether the new drug could help people with ALS whose disease is caused by mutations in a gene called SOD1 [19659003] The test is designed to assess the safety of substance use in humans, and different dosages and regimes are currently being tested to find the optimal formula and the most effective way to reduce levels. of SOD1 without causing serious side effects. About 10% of cases are inherited. Of these, about one-fifth are caused by mutations in SOD1. These mutations make the gene proteins hyperactive, suggesting that reduced levels of protein may help patients
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