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The effectiveness of antibiotics may be impaired by combining them with other antibiotics, drugs or even certain food additives. Depending on the species of bacteria, certain combinations can stop antibiotic abilities, according to a new study.
In one of the largest studies of this type, researchers have determined 3,000 drug combinations that can treat three different types of bacterial diseases. According to Science Daily, excessive or abusive use has increased bacterial resistance to antibiotics.
Certain specific drug combinations can help destroy bacterial infections resistant to several types of drugs, but largely unused in clinics. In the paper, the researchers tried to discover the effects of combinations of antibiotics with each other, but also with other drugs or food additives.
For the most part, drug combinations stopped the effects of antibiotics. They found more than 500 drug combinations that alter the effects of antibiotics. A selection of positive associations was tested for multidrug-resistant bacteria and the effects of antibiotics were improved.
When vanillin was associated with the antibiotic spectinomycin, it helped the drug to penetrate the inside of the bacterial cells and to inhibit their growth. Spectinomycin was developed in 1960 for the treatment of gonorrhea, but is currently rarely used because of the resistance of the bacterium to the drug. In combination with vanillin, it could again be effective in clinical treatments. It is odd that vanillin has altered the effects of other antibiotics in the same way as aspirin.
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