About the mixing of doses of corona vaccines .. this is confirmed by world health

Dr Catherine O’Brien, WHO head of vaccines and immunology, said there are currently more than 17 vaccines in use worldwide and most countries have more than one vaccine in use in the vaccination program against the Corona virus and its variants.

In the 54th episode of the show “Science in Five”, presented by Vismita Gupta Smith, and broadcast by the World Health Organization on its official accounts on communication platforms, Dr O’Brien added that he There is no evidence for the validity of what vaccines are said to be similar and therefore possible to get on one dose of one product and a different dose on another.

MRNA transcripts

Dr O’Brien explained that while no evidence has been found that most of these mix-and-match procedures are feasible, there is already some evidence that a first dose of AstraZeneca can be combined with one of the mRNA-based vaccines. , such as the Pfizer and Moderna vaccines.

“What we do know is that a person gets a better response if they start with the AstraZeneca vaccine and then get the mRNA vaccine or vice versa,” she explained.

Both approaches can achieve a result and are a safe procedure. Either way, there is still no evidence for the effectiveness of other mixed systems, as the results of current trials of mixing mRNA and other vaccines have yet to be released.

safe approach

And Dr O’Brien added that results from clinical trials, which combine the first dose of AstraZeneca, Pfizer, or Moderna and then the second dose of the other vaccine, or vice versa, have indicated that it is of a safe procedure with regard to the amount of reaction on the arm and some general short term reactions that can be done. That some are exposed, or that the fever is low.

She noted that the safety guideline for mixing mRNA vaccines is important because any recommendations issued by the World Health Organization must already take into account safety standards.

expressive

Usual routine

On the issue of partial doses, Dr O’Brien said the procedure is not limited to Covid-19 vaccines, but is being tested for other vaccines as well, noting that clinical trials on these partial vaccines have mostly been focused on exploring what dose people should receive, and therefore the doses that have circulated to date have been shown in clinical trials to offer very high protection against severe cases of Covid.

Dr O’Brien added that WHO experts are aware that in the future there may be evidence that booster doses may be needed, or that the dose of certain vaccines, in order to obtain better results.

Dr O’Brien indicated that clinical research is currently underway to see if a small part of the usual dose may be effective, pointing out that there is no answer to this question yet, but it certainly is. an area that is being looked at carefully. and experts expect that in the future there will be evidence available as to whether partial doses or additional boosters are needed, and whether we should use the currently vaccinated full dose as baseline doses, or whether a small part of this dose should be obtained.

No to partial doses

Dr O’Brien cited similar research, which has already been done on other vaccines to improve the results of their vaccination and the success of disease control campaigns, such as vaccines against polio, yellow fever. et al, explaining that clinical research in this area is not new or has never been explored before with vaccines. Rather, they are steps that are taken for many vaccines to improve the amount of supply available and to achieve the best immune response with the highest degree of safety.

She concluded: “Therefore, until research in this area is mature and results supported by evidence become available, scientific experts at the WHO are not currently recommending split (or partial) doses. “