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A team of researchers at Northwestern University in the United States has discovered a human protein that helps fight the Ebola virus in humans.
The researchers used mass spectrometry, a technique that identifies specific elements in the mass sample, to look for interactions between human proteins and Ebola proteins. They also demonstrated an interaction between the Ebola protein (VP30) and the human protein (RBBP6).
In addition, structural and arithmetic analyzes reduced the interaction to a small series of peptides of 23 long amino acids. This small group of amino acids alone is enough to disrupt the life cycle of the Ebola virus.
"If we take this peptide and introduce it into human cells, you will be able to prevent Ebola infection," said Dr. Goodtquist, assistant professor of infectious diseases at Northwestern University School of Medicine. On the contrary, when the human protein (RBBP6) human cells, the Ebola virus repeats itself more quickly.
"The question now is whether we can manipulate them in an effective pharmacological manner so that they have therapeutic value," said Dr. Nevan Krugan, professor of cellular and molecular pharmacology at the University of California. University of California at San Francisco. "What we are considering is to develop a small molecule human protein drug, and can be used in the event of an Ebola outbreak."
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