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A team from the Institut Pasteur in France identified a vulnerability in the "stored" cells of the AIDS virus, opening it to a study published in the journal Metabolism. Current HIV treatments last a lifetime because they fail to eliminate the virus stocks of immune cells.
"Antiviral drugs disrupt viruses and act against them to suppress their proliferation, but they can not kill infected cells," said Asier Sayes-Sirion, the study's supervisor. Through our research, we have been able to identify infected cells to target them and rid the body of people infected with HIV.
The team was able to identify the properties of CD4 cells, which are the main target of the virus, and showed that these first applied to cells with significant metabolic activity. This activity, especially the glucose consumption of the cell, plays a key role in the infection: the virus "disperses" the energy and cell yield to multiply.
This virus is a vulnerability that can be exploited to attack "stored" cells.
The researchers were able to stop the infection through molecules mimicking metabolic activity, a method also used in the field of cancer.
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