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Study: Cholesterol-lowering drugs can weaken muscles and the nervous system
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Monday 07 January 2019 – 20h38
Drugs that lower cholesterol levels in the blood, such as the statin, can weaken the muscles and nervous system, according to a US study.
According to the study published in the journal "Cell Metabolism", a statin that reduces cholesterol reduces the formation of brown adipose tissue that helps convert sugar and fat into energy. People with structured adipose tissue better regulate their body temperature in the winter and are less likely to suffer from excess weight or diabetes.
Researchers at the New York University School of Medicine have examined how bad white fat cells, which form the subcutaneous fat layer, become well-structured fat cells.
After conducting cell culture experiments, the researchers found that the biochemical pathway responsible for cholesterol production plays a central role in this transformation and they also discovered that the key to regulating transformation is "pyrophosphate".
The researchers found that 8% of those who did not take cholesterol-lowering drugs had brown, oily tissue, but this type of tissue was present at 1%. Among patients enrolled in statin therapy, a cholesterol-lowering drug is used to reduce the activity of brown adipose tissue.
The researchers pointed out that cholesterol-lowering drugs should be considered as a major fat-reducing factor, but that this type of drug should not be stopped because of its very important role in the prevention of vascular disease.
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