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National Institute of Allergic and Infectious Diseases – …
An international scientific team has discovered a way to reactivate T cells that have exhausted their forces when fighting cancer cells.
According to MedicalXpress, one of the reasons the human immune system can not beat cancer is that cells lose energy when cancer cells attack, because cancer cells efficiently absorb glucose, thus depriving T cells of their source. d & # 39; energy.
The researchers found that the cause of immune cell depletion is the decrease in the amount of Enoliz 1, which plays an important role in the burning of sugar.
This results in weak oxidative phosphorylation in which energy is conserved as adenosine triphosphate molecules. To prevent this, the researchers forced the cells to absorb pyruvic acid (the final product of the oxidation of sugar), which increased the energy of the lymphocytes and increased their effectiveness.
The researchers developed a compound of inhibitory substances and tested it on laboratory mice. The researchers observed slow tumor growth in these mice and therefore plan to test it on sick volunteers.
Source: Linta. ro
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