Study: Excessive obesity weakens renal function

(Reuters) – A large-scale study suggests that kidney function deteriorates with an increase in obesity, whether or not it has kidney problems.

The study found that obese adults are twice as likely to have kidney failure as overweight adults.

"Overweight, especially around the abdomen, causes many negative metabolic effects on the kidneys," said Dr. Alex Chang, lead author of the study.

This excess weight can activate the sympathetic nervous system or the nervous system that secretes hormones that can increase sodium retention and increase blood pressure, Zhang said by email. It also makes it difficult for the body to get rid of the extra sugars in the blood leading to diabetes.

All of these things are detrimental to the kidneys, Zhang said, adding that inflammation associated with obesity and excess abdominal fat also weakened kidney function.

"First, overweight increases the activity of the sympathetic nervous system and the hormones that result in increased sodium retention and high blood pressure … Second, excess weight weakens the body's ability to transfer the glucose from the blood to the cells and can lead to diabetes. "

According to WHO data, 1.9 billion adults are overweight or obese in the world. About four out of 10 adults suffer from weight gain and about one in 10 adults is obese, which can increase the risk of heart disease, diabetes, joint problems, certain cancers and kidney problems.

For this study, the researchers examined data collected from 1970 to 2017 relating to over 5.4 million adults from 40 different countries in Asia, Europe, the Middle East and Africa. 39, North America. They also examined data from more than 84,000 people at risk for cardiovascular disease and more than 19,000 adults with chronic kidney failure.