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A team of Swiss researchers has developed a new method of treating diabetes based on reprogramming a type of pancreatic cell to produce insulin and transplanting it to help the pancreas function properly.
In their study, published in the latest issue of the scientific journal Nature, researchers relied on the modification of the genetic code of certain alpha and beta cells in the pancreas of certain diabetics, and then on the transplantation of diabetic mice.
The pancreas contains a number of endothelial cells divided into five types, including alpha, beta and gamma cells, insulin being produced in special beta cells, which are produced and then injected directly into the blood. In these cells, it is necessary to stop the manufacture of insulin, which prevents the pancreas from pumping this hormone into the blood, and to force the wounded to compensate for the lack of industrially manufactured insulin injections. .
After cultivating the genetically modified cells, the researchers verified that they were able to alleviate the clinical symptoms of diabetes. The modified cells started to produce insulin and inject it into the blood four weeks after implantation, and then excrete it until six months after implantation. .
The World Health Organization estimates that there are more than 400 million people with diabetes, which varies according to the three types of diabetes. This is the first type of diabetes in which the body is unable to produce insulin and can not be prevented using current knowledge, the effectiveness of the use of the drug. insulin by the body, and the third affects pregnant women.
The results of the study are very important evidence of the resilience of human pancreatic cells, which can compensate for the loss or dysfunction of cells naturally producing insulin and benefit mainly to type 1 diabetes.
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