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Sani, who scored a great free kick in the 86th minute after Nabil Benalib had two penalty shots in the 38th and 45th minutes, gave Schalke the lead.
And put Sergio Aguero City leading in the 18th minute and completed Champion of England The match ten men after the dismissal of Nicolas Otamendi in the 68th minute for a second warning.
City, who conceded at least two goals in six of his seven knockout matches with the coach Pep Guardiola, The return match to Manchester on March 12 without Fernandinho will be suspended due to suspension.
Sani, a graduate of Schalke Youth Academy, told reporters, "We knew we would have a chance to register and we would use them more often.
"I was lucky enough to enter the goal of this place, we struggled to adapt to the game and had trouble finding space."
Argentina Aguero, who has scored three goals in the last three games, English Premier LeagueScore with an easy touch after a pass by goalkeeper Ralf Farman.
City completely dominated his German counterpart at first, but instead of digging out, he fell inexplicably and allowed Schalke to progress.
The referee stepped in to score a penalty for the local team after a handball against Ottamendi, who received an ultimatum.
Schalke surprised his guest by offering another penalty after Fernandinho's naive intervention against Salif Sani.
Bantalab came back and threw the ball, but goalie Ederson touched the ball.
With Guardiola's anger increasing, the visitors were looking for a draw at the start of the second half but had to face Schalke's organized defense.
Things got spoiled after Otamende 's dismissal in the 68th minute, but Sani saved the English team from a free kick.
Stirling decided to win the third goal in the end.
"It's a good thing," said Schalke midfielder Daniel Caliggiore. "A bitter and painful defeat, we had to control the ball and make the score 3-1 as we played more player, we had to better handle this situation."
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Sani, who scored a great free kick in the 86th minute after Nabil Benalib had two penalty shots in the 38th and 45th minutes, gave Schalke the lead.
Sergio Aguero City took advantage in the 18th minute and the champions of England completed the match with 10 men after Nicolas Ottamende was ejected in the 68th minute for a second caution.
City, which has conceded at least two goals in six of its seven knockouts with Pep Guardiola in the Champions League, will play the Manchester City return match on March 12 without Fernandinho, who will be suspended.
"We knew we would have chances to sign up and we would use them more often," said Sani, a graduate of the Schalke Youth Academy.
"I had the chance to get into the ball from this place, we had trouble getting into the game and we had to have room."
Aguero, who has scored three goals in the last three Premier League games, opened the scoring with an easy touch after a foul by goalkeeper Ralf Farman.
City completely dominated his German counterpart at first, but instead of digging out, he fell inexplicably and allowed Schalke to progress.
The referee stepped in to score a penalty for the local team after a handball against Ottamendi, who received an ultimatum.
Schalke surprised his guest by offering another penalty after Fernandinho's naive intervention against Salif Sani.
Bantalab came back and threw the ball, but goalie Ederson touched the ball.
With Guardiola's anger increasing, the visitors were looking for a draw at the start of the second half but had to face Schalke's organized defense.
Things got spoiled after Otamende 's dismissal in the 68th minute, but Sani saved the English team from a free kick.
Stirling decided to win the third goal in the end.
"We had to take control of the ball and take the score to 3-1 and we play more," said midfielder Daniel Caliggiore of Schalke 04.
