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Low levels of amyloid-tao protein, essential markers of Alzheimer's disease (AD), in ocular fluid are largely associated with weak cognitive points, according to a new study published in the journal Alzheimer's Disease .
The study, conducted by researchers at the Boston Medical Center, is the first to link these vital signs known as the protein "Amyloid Town" in the mental state of the eyes.
These results suggest that proteins present in the eye could be a potential source for an affordable and cost-effective test to predict Alzheimer's disease in the future.
Diagnosis and initiation of pre-symptomatic treatment are essential for the management of the disease, because at the time of onset of symptoms, it is often too late for current treatments to have a significant effect.
Abnormal amounts of amyloid protein and thaw protein are biological markers of Alzheimer's disease, and amyloid protein deposits begin in the brain many years before the onset of symptoms.
Previous research has shown a link between low levels of amyloid-tao proteins in cerebrospinal fluid obtained by lumbar puncture and preclinical disease, when pathological changes occur in the brain but before onset. clinical symptoms. Lumbar is expensive and uncomfortable for many patients.
In this study, the researchers used ocular fluid samples from 80 patients who had to undergo surgery, and the fluid extracted during these surgeries is usually eliminated.
The researchers tested the eye fluid to determine levels of amyloid-thawed protein and linked these rates to the results of a basic cognitive test.
Low levels of these proteins have been associated with significantly lower cognitive scores in patients.
"These findings can help build an accessible test with the least possible intervention to determine the risk of Alzheimer's disease, particularly in patients with vision disorders," says Lauren Wright, MD, first researcher and ophthalmologist at BMC. Some participants with low levels of protein biomarkers in ocular fluids already show signs of mild to moderate dementia based on their cognitive qualities. "
The findings also reaffirm previous studies indicating that ocular patients are at risk for developing Alzheimer's disease and suggest that further studies in patients with ocular diseases could produce results that can be generalized to larger populations .
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