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Viagra is the brand name of Sildenafil and today, March 27, we celebrate the 21st anniversary of its ratification. We know here the story of his discovery: how it was not originally intended to treat erectile dysfunction, and that this feature was discovered by chance.
Viagra was manufactured by a group of pharmaceutical chemists working for Pfizer in England.
Researchers first studied the use of this drug in the treatment of high blood pressure and angina pectoris. The first clinical trials were conducted at Morriston Hospital in Swansea, UK.
Viagra was first discovered in the treatment of erectile dysfunction and its researchers began by studying cardiovascular disease, which is believed to dilate the blood vessels of the heart by blocking a protein called PDE-5 in animal tests.
When testing on animals, Sildenfeld seemed to work well. The researchers found that it was blocking PDE-5 and no obvious negative side effects have been observed in animals.
Experiences
Sildenafil was introduced in clinical trials in humans in the early 90's, but the bad news is that early results showed that the drug had little effect on angina pectoris .
The nurses who supervised the men involved in the study observed this strange story – which will become good news -. John Lamatina, who was responsible for Pfizer's research and development during the research, said many of them went to bed and were embarrassed because they felt right .
Dilated blood vessels were not in the heart but in the penis, and since vasodilation was an essential part of the process leading to the erection, the result was spectacular. Pfizer decided to market the drug to treat erectile dysfunction rather than angina.
The patent was registered in 1996 and approved by the US Food and Drug Administration on March 27, 1998 for the treatment of erectile dysfunction. It has become the first oral treatment for erectile dysfunction in the United States.
Viagra has become one of the biggest successes of the pharmaceutical industry: its annual sales in 2008 reached $ 1.934 billion in 2008 and, since 2012, the United States, Mexico and Canada spend about 1.4 billion dollars a year.
These numbers are expected to decline in the coming years as Pfizer's patent expires in 2020.
Viagra works by responding to sexual stimulation, increasing blood flow to the penis, leading to erection, but on the other hand does not increase libido and does not lead to penis erection without catalyst.
What are the caveats and recommendations?
The dosage should be determined by the doctor, usually between 25 and 50 mg before an hour of intercourse.
Make sure the person is not taking any medications that may cause complications with Viagra, such as nitroglycerin and isosorbide, which can cause a fatal drop in blood pressure.
Patients with chronic conditions such as heart and high blood pressure should consult your doctor before using Viagra.
What are the side effects?
The most common side effects are headache, facial redness, heartburn, vision problems, nausea and dizziness.
This article is a "funny story behind the discovery of Viagra". It does not reflect in any way the site policy or point of view, and that the responsibility lies with the actuality or authenticity of the source of the actuality of origin, which is the news of the country.
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