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The new age “clock” is used to assess chronic inflammation and the risk of developing cardiovascular and neurodegenerative diseases, and against which the “biological age” of a person is determined.
And the journal Nature Aging notes that the iAge is a new type of clock that differs from previous clocks that rely on evaluating a person’s DNA as they age.
And the “circadian clock” (iAge) calculates age based on chronic age-related inflammation. The inventors of the watch hope that once the inflammation is treatable, it can help doctors decide how to treat the inflammation so that the body remains healthy for its current age.
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“This study confirms that the state of the immune system is important not only for predicting unhealthy aging, but also as a trigger for the mechanism of unhealthy aging,” says Dr. Vishwa Deep Dixit, an immunologist at the University of Medicine School of Medicine. Yale.
The researchers designed this watch on the assumption that the body with age exhibits chronic inflammation. Thus, cells are damaged and release molecules that cause inflammation, which ultimately leads to erosion of tissues and organs. Therefore, people with healthy immune systems can neutralize these infections over time, while others show signs of aging rapidly.
To design the iAge watch, the team of biologists and doctors relied on the analysis of blood samples taken from 1001 people aged 8 to 96 years who all participated in the 2009-2016 project “1000 immune cells” organized by Stanford University School of Medicine, a large-scale, long-term study of disease markers Chronic disease that changes with age.
Using a machine learning algorithm, the researchers used information about the age and health of the participants to identify protein markers in the blood that clearly indicate chronic inflammation. The cytokine family protein CXCL9 has been shown to contribute to cardiac aging, structural damage and dysfunction, as well as vascular function.
Thus, the CXCL9 has become an essential part of the iAge watch, he says. It gives new meaning to the old adage, “Your age is exactly as old as your arteries.”
The researchers obtained blood samples from 29 centenarians from the Italian city of Bologna and compared their inflammatory age to that of 18 participants aged 50 to 79. It turns out that the inflammatory age of Bologna centenarians was, on average, 40 years younger than their orthodontic age.
Dr Maria Mittelbrunn, a molecular biologist at the University of Madrid, explains that assessing human age by measuring changes in DNA is a complex process, while identifying infections by blood test is easy. This means that this watch is easy to use in a hospital setting.
Source: Vesti. Line
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