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MOSCOW (Reuters) – Two molecular biologists from Moscow and Boschino have discovered why the success of one of the most promising drugs in cancer treatment has been "resuscitated" by two mice. Scientists have published their findings in the International Journal of Molecular Sciences, Many mechanisms protect them from the accumulation of transitions in cells and destroy them that can turn into malignant tumors, before they start to multiply.
Molecular biologists are now looking for ways to activate genetic "instructions" in cancer cells that destroy them without resorting to chemotherapy or radiation therapy.
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Scientists from the Institute of Experimental and Experimental Biology of the Russian Academy of Sciences in Bucheno hope that TRAIL can help cancer cells to treat malignant tumors and produce their industrial counterpart, izTRAIL, which s & # 39; 39; is shown to be effective in destroying malignant tumors in clinical trials. But later, doctors discovered that some cancer cells became resistant to this protein even in laboratory tests outside the body.
Roman Fadyev and his scientific team investigated the cause of this problem and developed an effective anti-cancer drug based on industrial protein izTRAIL, whose experiments on laboratory mice devoid of immune system showed that the effect of this "killer" protein on cancer cells was highly dependent, not only on the internal characteristics of the tumor but also on the size of the "population density" in the test tube and the distance that separates them.
This has led scientists to think that cancer cells become resistant to this protein through a "collective protection" that inhibits the action of izTRAIL protein molecules. On this basis, the researchers decided to add two other types of anti-cancer molecules: "sorafenib" and "iRGD", which prevent the "convergence" of cancer cells of this protein, and showed the results of this compound screening test , which completely slows the growth or elimination of cancerous tumors in the body of the mouse. And researchers believe that similar problems can be the cause of failure of other medical preparations. They should therefore be re-examined to increase their effectiveness.
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