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A team of scientists from the National University of Russian Technical Research, "Misses", together with colleagues from the Institute of Technology of Central Europe (born in the Czech Republic), as well as from Other Czech universities, designed a biodegradable antibacterial material, intended to be used in dressings of the affected skin.
It should be noted that the use of this substance in dressings has an objective impact and that to maintain this effect for a long time does not require the change of dressing, which underlines the possibility of applying a new dressing directly on l & # 39; old. We recall that this article was published in the magazine Materials and Design.
The bandages date back several centuries and are associated with the names of Abu Qarat, Paracelsus and other internationally renowned doctors. It will be remembered that old dressings were made of linen and wool, saturated with oils. In the 19th century, Nikolai Berogov, a Russian scientist and doctor, proposed a wound-cleaning treatment by cleaning it with a solution and using gauze bandages that increased liquid leakage.
However, the recent treatment of burns and wounds requiring treatment with a disinfectant and a regular change of dressing has resulted in side effects. For example, antibiotics kill not only dangerous bacteria, but also useful bacteria. When the bandages change, the tissue structure that has just been damaged is damaged, which is very painful for the patients.
Here, scientists from the University of Mississle, in collaboration with their European colleagues, have designed a biocompatible material that can locally affect the inflamed area and not requiring change by releasing the antibiotic that gradually melts the skin. If necessary, the new dressing can be placed on the old one.
Elisabetta Perniakova, researcher at the Laboratory of Inorganic Nanomaterials, said:
"We used polycaprolactone nanoparticles as a basis for our design, it is a biocompatible, self-absorbing material, we have integrated a broad-spectrum antibiotic with gentamycin fibers. significant reduction in the number of bacteria 48 The hours of application of the substance, generally the antibacterial surface, have a net effect during the first days, or even the first hours of use.
The experiment was performed using three strains of E. Coli (Escherichia coli). All three strains had different antibiotic resistance, but a strong antibiotic effect was observed in all three cases.
Scientists also suggest that the substance will likely be used not only to treat the skin, but also to treat bone diseases, such as osteoporosis and osteoporosis.
Scientists continue to test and improve equipment. Other antibiotics, such as ciprofloxacin, should be incorporated. These antibiotics belong to a new generation and most of the bacteria have not evolved according to their resistance. In addition, it is planned to increase the effectiveness of the material by designing multilayer samples (antibiotic and heparin to reduce blood clotting at skin surface lesions and again antibiotics). ).
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