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A team of scientists found Institute of Cancer Research In London That this ring calls b "Koheisen" Cohesin helps stop DNA copies when it is badly damaged.
The researchers also found that when Cohesin can not protect DNA, it repairs the imbalance that can lead to cancer.
The Cohesin ring is made up of a number of proteins that act together to secure the DNA strands in place, such as a cord.
These proteins are often mutated in Cancer cellsFor example, about 20% of bladder cancer cases have a Cohesin SA2 mutation.
This has led many researchers to conclude that cohisin helps prevent cancer by stabilizing chromosomes together during cell division, thus ensuring that cells have the right number of chromosomes in the end.
However, the team at the cancer research institute of Professor Jessica Downs believes that this cohesion also plays a role in cancer prevention because some cancers containing mutations in Cochin proteins do not contain the wrong number of chromosomes.
Preventing the disorder in the genome
This new research reveals a mechanism to prevent cloning of DNA in the field of DNA sequencing.
The team also demonstrated that when the compound was unable to prevent DNA transfer near sites with linear damage, there was a significant rearrangement of DNA sequences, including including damaged parts of the chromosome.
Downes said "Although cohesin proteins often turn into cancer, we do not really know how to help prevent the disease." But added "Research has revealed the ability of these proteins to suppress the cloning during DNA breaks, which helps to stabilize the genome ".
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A team of scientists at the Cancer Research Institute in London has discovered that this ring, called Cohesin, helps stop DNA replication when it is badly damaged.
The researchers also found that when Cohesin can not protect DNA, it repairs the imbalance that can lead to cancer.
The Cohesin ring is made up of a number of proteins that act together to secure the DNA strands in place, such as a cord.
These proteins are often mutated in cancer cells: for example, about 20% of bladder cancer cases have a SA2 cohesin mutation.
This has led many researchers to conclude that cohisin helps prevent cancer by stabilizing chromosomes together during cell division, thus ensuring that cells have the right number of chromosomes in the end.
However, the team at the cancer research institute of Professor Jessica Downs believes that this cohesion also plays a role in cancer prevention because some cancers containing mutations in Cochin proteins do not contain the wrong number of chromosomes.
Preventing the disorder in the genome
This new research reveals a mechanism to prevent cloning of DNA in the field of DNA sequencing.
The team also demonstrated that when the compound was unable to prevent DNA transfer near sites with linear damage, there was a significant rearrangement of DNA sequences, including including damaged parts of the chromosome.
"Although cohesin proteins are often converted to cancer, we do not really know how to help prevent the disease," Downes said. "Research has revealed the ability of these proteins to suppress cloning when DNA breaks down, genome".
