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To expandMohammed Jawdallah: When the An-Najah National University placed the center of scientific research at the center of its strategic plan, its vision was to bring out its ambassadors who are the best representatives in different countries, forums and universities of the world. . In selected scientific journals.
Yousef Mahmoud Salameh was one of these ambassadors, graduated from the Biotechnology Department of the Faculty of Science of An-Najah National University in 2009, and distinguished scholar, he was a research assistant and a researcher. teaching at the university before finishing his graduate studies in 2012 in Japan.
In Japan, Dr. Salama is active in cancer and stem cells before becoming one of the best researchers in this field, not only at the Japanese level, but also at the global level.
Recently, a team of researchers at the University of Tokyo Institute of Medical Sciences managed to find a new mechanism for identifying the proteins and receptors found on cancer cells responsible for melanoma, including the first author and member from the research team of the University of Tokyo.
Melanoma accounts for about 1% of skin cancers, but is responsible for the vast majority of deaths due to this type of cancer, according to the American Cancer Society. Tumors of melanoma develop more than others, most often because of interactions between a couple of molecules, and by the process of proliferation called metastasis, tumors reach the lungs, liver, spleen and others. body organs.
According to experiments conducted on mice and human cells, a large tumor is formed during the injection of this type of cancer cells, causing the death of injected mice in less than a month. of the research team are likely to restore a type of cancer treatment that was abandoned Previously, the results suggest that a molecule is already associated with obesity and dementia as a possible cause of malignancy, or the spread of cancer cells to other parts of the body.
It should also be noted that the team of Tokyo University of Medicine led by Associate Professor Betty Hessig studied the protein (plasminogen activator) and shortened the name (tPA) for a long time and that during More than a decade ago, the cancer cells that produce the protein (tPA) It also produced large amounts of receptors for this protein called (LRP1) and, through experiments, the team concluded that the inhibition of the protein or associated receptors leads to a significant decrease in the proliferation of cancer cells.
"A better understanding of the specific interactions between PRL and TPA gives us hope that it will lead to a cure for cancers resulting from TPA and activity, while maintaining the ability to maintain normal processes." and important protein protease in the body, "said Dr. Salama.
Dr. Salama also suggests that gene therapy can be associated with cancer immunotherapy when the mechanism used by cancer is targeted by proteins, allowing the immune system to function and prevent the spread of cancer in the body.
"When we experimented with mice by injecting them with transgenic cancer cells by removing the genes that produce the TPA, LRP1 proteins, we found a significant halt in the proliferation of cancer cells, so the rats were able to live at almost the same age as normal mice, "said Dr Salameh on behalf of the research group. That has not been injected with any type of cancer cells. "
This new discovery is a giant leap forward in the development of a new mechanism to reduce the spread of this high-risk, deadly cancer by detecting the positive relationship between TPA and LRP1 proteins. This discovery could place us at the threshold of a new therapeutic age based on the manufacture of drugs, new treatments that can target mainly tumor mutations of tumors.
The new discovery was published in a well-known scientific journal on molecular genetics (THE FASEB JOURNAL). Dr. Salameh was named first editor and the name of the An-Najah National University was named in the journal.
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