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Scientists from the University of Utah have discovered a way to treat autoimmune diseases, including multiple sclerosis and type 1 diabetes.
In the article published in the journal Nature Biomedical ngineering, the researchers point out that they have developed an immunosuppressant that destroys cells containing a distorted PD-1 protein, a checkpoint that blocks the cells. T cell activity and helps them to destroy themselves Linta. Ro ".
The transformation of the "PD-1" gene helps to develop the reaction of tissues and organs of the body, causing various diseases. At the same time, the limitation of "PD-1" with the help of barrier inhibitors is an effective way of boosting immunity against cancerous tumors.
The researchers tested the immune toxin developed by the researchers in mice with type 1 diabetes, which slowed the progression of the disease for 10 weeks. In mice with an autoimmune disease (MS), the symptoms of the disease, including paralysis, decreased. The use of this immune toxin reduced the number of cells containing the active PD-1 protein, as well as the number of T cells in the inflamed organs.
If this method is also effective in treating people, doctors will first receive treatment for multiple sclerosis, as current methods used to treat the disease only prevent its development.
This immune toxin, along with other treatments, can prevent type 1 diabetes.
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