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For the first time, researchers have shown how the mechanical forces of joint cells during exercise prevent the deterioration of cartilage by inhibiting the work of inflammatory molecules responsible for arthritis. Thus, this anti-inflammatory effect is the result of the activation of a specific protein called HDAC6: it was observed that drugs preventing the activation of this protein inhibited the anti-inflammatory effects of Physical activity, while other pharmaceutical treatments could simulate the benefits of exercise.
The researchers hope that these results will help find treatments for arthritis, which affects millions of people around the world.
The researchers suggest that the results could lead to a whole new therapeutic approach called mechanical medicine, in which drugs mimic the influence of mechanical forces to prevent the damaging effects of inflammation and treat various conditions, such as arthritis.
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