Scientists identify compounds in coffee that can inhibit prostate cancer



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For the first time, scientists have identified compounds found in coffee that could inhibit the growth of prostate cancer. This is a pilot study of drug-resistant cancer cells in cell culture and in a mouse model. it has not yet been tested in humans. This work is presented at the Congress of the European Association of Urology in Barcelona, ​​after publication in the peer-reviewed journal The Prostate * (this press release contains additional information).

Coffee is a complex mixture of compounds whose positive and negative influence on human health has been demonstrated. It is increasingly evident that the consumption of certain types of coffee is associated with a reduction in the incidence of certain cancers, including prostate cancer **. Japanese scientists have studied the effects of two compounds found in coffee, kahweol acetate and cafestol, on prostate cancer cells and in animals, where they have been able to inhibit the growth of drug-resistant cells anticancer agents such as cabazitaxel.

The researchers initially tested six compounds, naturally present in coffee, on in vitro proliferation of human prostate cancer cells (ie, in a petri dish). They found that cells treated with kahweol acetate and cafestol developed more slowly than control cells. They then tested these compounds on prostate cancer cells that had been transplanted into mice (16 mice). 4 mice were controls, 4 were treated with kahweol acetate, 4 with cafestol and the remaining mice were treated with a combination of kahweol acetate and cafestol.

The director of the study, Dr. Hiroaki Iwamoto (Department of Integrated Treatment of Cancer and Urology, Graduate School of Medical Sciences of Kanazawa University, Japan, first author of the study) said:

"We found that kahweol acetate and cafestol inhibited the growth of cancer cells in mice, but that the combination seemed to work synergistically, leading to significantly slower tumor growth than in non-mouse. After 11 days, the untreated tumor had increased from about 3 to one and a half times the initial volume (342%), whereas tumors in the mice treated with both compounds had increased by a little more than one and a half times (167%) the initial size.

It is important to keep these results in perspective. This is a pilot study, so this work shows that the use of these compounds is scientifically feasible, but requires further research. this does not mean that the results can still be applied to humans. We also found a reduction in growth in grafted tumor cells, rather than in native tumor cells. This shows that these compounds seem to have an effect on drug-resistant cells, prostate cancer cells under the right circumstances, and that they also need to be deepened. We are currently thinking about how we could test these results in a larger sample and then in humans. "

Kahweol acetate and cafestol are hydrocarbons, naturally present in Arabica coffee. It has been found that the process of making coffee has an impact on whether these compounds remain in the coffee after being brewed (as in an espresso) or if they are removed (as they are filtered).

Professor Atsushi Mizokami (Department of Integrated Treatment of Cancer and Urology, Graduate School of Medical Sciences, Kanazawa University, Japan) added:

"These are promising results, but they should not encourage people to change their coffee consumption.Coffee can have both positive and negative effects (for example, it can increase hypertension). However, if we can confirm these results, we could have candidates to treat drug-resistant prostate cancer. "

In an independent comment, Professor Zoran Culig (Professor of Experimental Urology at the University of Medicine Innsbruck) said:

"These are interesting results, and I think these first results will encourage researchers to use more recent models, such as xenografts derived from androgen-receptor-expressing patients, which will probably provide a definitive answer for future perspectives of this type." . treatment. "

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Type of study: experimental study / animals / peer review

* See: kahweol acetate and cafestol, coffee diterpenes, synergistically inhibit the proliferation and migration of prostate cancer cells, Iwamoto et al, Prostate. 2018; 1-12. https: //onlinelibrary.Wiley.com /do I/ten.1002 /advantages.23753

** See: Coffee Reduction of Prostate Cancer Risk Consumption: Evidence from the Moli-sani Cohort and Cell Models, George Pounis et al (International Journal of Cancer, 2017), https: //onlinelibrary.Wiley.com /do I/pdf /ten.1002 /LBI.30720

This work was funded by JSPS KAKENHI, grant numbers: 16K10998, 17K11126.

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