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In a clinical trial, researchers reported having developed a first vaccine against the AIDS virus. The results are very encouraging, although caution is still needed.
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On July 7, 2018, and after 35 years of epidemic and unsuccessful research, researchers report very encouraging results concerning the implementation to the point of an HIV vaccine, the AIDS virus. In fact, a clinical trial of an experimental vaccine elicited an immune response in humans, and protected from rhesus macaques from infection
The results of this first trial were published in The Lancet. The team tested the new vaccine agent created on 393 healthy, HIV-free adults from East Africa, South Africa, Rwanda, Uganda, the United States and Thailand, aged 18 years. at 50 years old. All participants were randomly divided into seven groups and given severe combination combinations or placebo. This is called a "mosaic" of vaccines. They received 4 injections over a period of 48 weeks and their immune response was then measured. According to the authors of the study, the vaccine produced "robust immune responses" in participants . Only five of the recipients of the vaccine reported side effects such as dizziness, diarrhea, stomach pain, lower back pain, etc.
And among the 72 primates (rhesus macaques) having received this vaccine candidate, two-thirds (67%) of individuals had their immune system resist HIV infection proving the effectiveness of this vaccine prototype.
The next step, decisive for Validating this vaccine potential will be testing it on 2,600 women in southern Africa to see if it protects them from HIV infection. The drug (HVTN705) was named "Imbokodo", which means "rock" in Zulu. The results of this large-scale clinical trial are expected between 2021 and 2022.
While it remains very cautious, the scientific community has welcomed this advance, because it is the 5th prototype HIV vaccine since the onset of the virus. Led in 2009, the last vaccine candidate, RV144, led to a 31% reduction in the risk of infection in more than 16,000 Thai volunteers. But these results were considered too low to lead to the generalization of this vaccine.
Recall that some 37 million people are living with HIV in the world, according to the World Health Organization, and that 1 , 8 million people are infected each year. Since being first detected in the 1980s, AIDS has killed 35 million of the 80 million people infected
Source: News Medical
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