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A large prospective cohort study of half a million people in the UK found reverse associations for drinking coffee with mortality, including among participants drinking 1 to 8 cups or more a day, both slow and rapid metabolizers of caffeine, Loftfield et al have confirmed previous studies showing an inverse association between coffee consumption and mortality and found similar associations in participants with genetic variants transmitting both the metabolism of the caffeine faster and slower. Loftfield et al. confirmed earlier studies showing an inverse association between coffee consumption and mortality and found similar associations in participants with genetic variants that transmit both caffeine metabolism faster and more slowly. Photo Credit: Stock Snap
Coffee is popular around the world and studies have generally reported inverse associations (going in opposite directions) between its consumption and the risk of chronic diseases and mortality.
"The speed of caffeine metabolism varies greatly among people," said Dr. Erikka Loftfield of the Division of Cancer Epidemiology and Genetics at the National Cancer Institute and his colleagues. colleagues from Northwestern "Previous data from case-control studies had suggested that coffee consumption could increase the risk of hypertension and myocardial infarction in individuals with genetic variants indicating a greater metabolism. slow caffeine. "
"However, these earlier studies evaluated coffee consumption after the occurrence of the disease and did not examine mortality from cardiovascular disease."
Dr. Loftfield and his co-authors evaluated the coffee consumption habits of 502,641 people, using demographic, lifestyle and genetic data from the British Biobank
"The UK Biobank is a population study that has invited about 9, 2 million people We used basic demographic, lifestyle and genetic data from the UK Biobank cohort, with a follow-up from 2006 and ending in 2016, to estimate risk ratios for uptake of coffee and mortality. "We investigated the modification of potential effects by caffeine metabolism, defined by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism. "
likely to die of cardiovascular disease and cancer than non-drinkers.
Similar results were observed among participants ground coffee, instant and decaffeinated.
"All together, these results suggest that inverse associations between coffee and mortality can be attributed to components other than caffeine and can reassure coffee drinkers," say the researchers.
"Further research is needed to understand the underlying mechanisms"
The findings appear in the journal JAMA Internal Medicine .
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Erikka Loftfield and others . Association of drinking coffee with mortality by genetic variation in the metabolism of caffeine. Conclusions of the British Biobank. JAMA Intern Med published online July 2, 2018; doi: 10.1001 / jamainternmed.2018.2425
