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Hyderabad: Sleep stem cells repair and regenerate injured muscles, but these do not work in people with muscular dystrophy.
Scientists at the Center for Cellular and Molecular Biology (CCMB) have discovered a pathway that paves the way for further research to understand whether it can be developed to form drugs for those who suffer from the disease.
The research was published in Science Signaling on July 24th. The CCMB scientists say that this will require further research on dystrophic mice to understand if infusion of chemicals into the pathway can help heal.
there is traumatic injury, wear, or muscle damage in the skeletal muscles of the body. These cells are present in the muscle but are not active all the time. They are activated when there is muscle damage.
Dr. Jyotsna Dhawan, chief scientist at CCMB, along with his colleague Ajoy Aloysius identified a pathway in normal mice where stem cells were awakened during the injury and worked toward muscle regeneration.
Dr. Dhawan said, "The awakening of sleeping cells shows that the body's mechanism is in place to repair the damage." In those who are dystrophic, either the stem cells are depleted because of the burden of constant work, or they require outside intervention in which they can work for repair.This process is yet to be understood and requires further research on dystrophic mice. "
Dr. Rakesh Kumar Mishra, Director of CCMB, said the "cross-talk" between two signaling pathways works as a switch for stem cells.
Dr. Mishra explained: "This is an important phenomenon in biology because the change brings new hope that there is possible drug treatment in case of muscle disease."
The signaling mechanism is by two proteins called & # 39; Lef1 & # 39; and & # 39; Smad3 & # 39; who perform the work of switching genes.
million. Aloysius explained the alternative mechanisms that are in place, and said dormant stem cells are making new molecular partnerships during the process.
"The discovery will help design new therapeutic strategies to improve the stock of stem cells in diseased muscles.Pursuing this line of research can potentially improve muscle regeneration and reduce muscle wasting," he said.
Research is part of the basic science where the functioning of cells and their mechanisms have been studied. Muscular dystrophy is caused by a deficient X chromosome and mainly affects boys. It is a rare disease and most of those affected are not able to walk, become confined to bed and eventually die.
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