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A natural component found in cinnamon oil, known as cinnamaldehyde or CAD, could prevent bacteria Pseudomonas aeruginosa from spreading into an organism and inhibiting their ability to form antibiotic resistant biofilms.
These results could support further study of antimicrobial drugs that may help control the behavior of these bacteria, or treatment-resistant bacteria, which are a serious health problem for people with cystic fibrosis and others diseases. [19659003] The discovery was reported in " Cinnamaldehyde disrupts biofilm formation and teeming motility of Pseudomonas aeruginosa " published in the journal Microbiology .
"Humans have" Sanjida Halim Topa, Ph.D., researcher at the University of Swinburne.The history of using natural products in the treatment of infections is long and l & # 39; There is a growing focus on these antimicrobial compounds in Australia, and lead author of the study, said in a university press release. "Natural products can offer a promising solution to this. problem. "
Cinnamaldehyde, one of the major components of cinnamon oil, is responsible for its characteristic aroma.This compound is known to have antimicrobial activity against many bacteria, including P. aeruginosa; a bacterium causing a stomach ulcer called Helicobacter pylori ; and Listeria monocytogenes, which is responsible for infectious listeriosis. food origin [19] 659004] "We hypothesized that the use of natural antimicrobials, such as essential oils, could interfere in biofilm formation. "Although many previous studies have reported antimicrobial activity in cinnamon essential oil, it is not widely used in the pharmaceutical industry."
In collaboration with researchers from Nanyang Technological University, the team conducted several experiments. cinnamaldehyde on P. aeruginosa biofilms
They found that non-lethal quantities of the essential oil compound could disrupt 75.6% antibiotic resistant, preformed P. aeruginosa Biofilms. Cinnamaldehyde has been proven to prevent the production of a bacterial signaling protein essential for bacterial communication and biofilm formation. [Biofilmsandcommunitiesofmicrobeswhosegrowthisfacilitatedbythethickandstickymucosathathasbeenknowntopromoteantibioticresistancein P. aeruginosa pulmonary infections.]
In a concentration-dependent manner, cinnamaldehyde may also reduce the motility of bacteria, preventing them from spreading elsewhere, reported the researchers. .
CAD can disrupt biofilms and other surface colonization phenotypes by modulating intracellular signaling processes. "
They are now studying the use of cinnamaldehyde dressings as a treatment for cutaneous infections.
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