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New York – Administration of low-dose aspirin – a drug commonly used to treat pain, fever or inflammation – may help reduce plaques in the brain, reduce the pathology of the disease Alzheimer's and memory protection, revealed a study. ] The results showed that over-the-counter medication decreases the pathology of amyloid plaque (major signs of Alzheimer's disease) in mice by stimulating lysosomes – the component of animal cells that help clear cellular debris .
new role for one of the most used over-the-counter medications in the world, "said lead author and lead investigator, Kalipada Pahan of the Department of Neurological Sciences at Rush Medical College, in Chicago, Illinois. [19659002"Larechercheajustanotherpotentialadvantageablethepreviouslydevelopedaspinproductsforchildreleaseandforcardiovasculardiseasemanagement"commentedPahan
In the study, published in The Journa Neuroscience, the team gave aspirin orally for one month to genetically modified mice. Alzheimer's disease patients then assessed the amount of amyloid plaque in the brain parts most affected by Alzheimer's disease.
TFEB (a protein considered as the main regulator of waste disposal) stimulates lysosomes and decreases the pathology of amyloid plaque in mice. "Understanding how plaques are eliminated is important for developing effective drugs that stop the progression of Alzheimer's disease."
However, experts questioned the potential of aspirin, citing the failure of several recent major human trials in drugs that reduce amyloid plaques.
"A number of compounds reached this level of amyloid reduction in mice, which subsequently failed in clinical trials in humans," said Clive Ballard, of the University of Toronto. 39, Exeter, at newatlas.com [1965900] 2] "Chess may be the result of differences between Alzheimer's mice and human pathology, and poor translation of benefits into humans," he said. [19659002] In addition, in human clinical trials, the drug has been found to have "no beneficial effect on outcome measures and has been associated with an increased risk of gastrointestinal bleeding," noted Rob Howard, of the University College of London
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