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London, Nov. 4 (IANS) Some genetic factors can have a paradoxical impact on our body. A team of scientists has identified 14 new genetic variations linked to a higher body mass index (BMI), but potentially reducing the risk of diabetes, low blood pressure and risk of heart disease.
According to the researchers, this is because the geographic location – around the middle or the liver – where excess fat is stored could be genetically determined.
This location is more important than the amount with regard to insulin resistance and the risk of diabetes and other conditions.
"Some genetic factors increase obesity, but paradoxically reduce the metabolic risk.This is the place where fat is stored," said Brunel Alex Blakemore, a professor at Brunel University in London.
The results revealed that, when they gain weight, people with these genetic factors store it safely under the skin and therefore have less fat in their main organs such as the liver, pancreas and kidneys .
"Directly under the skin, it's better than around the organs or especially in the liver," added Blakemore.
For the study, published in the journal Diabetes, the team examined more than 500,000 people aged 37 to 73 years.
They used magnetic resonance imaging (MRI) scanners the size of these people to determine where they stored the excess fat, with signs of type 2 diabetes, heart attack, and risk of death. Stroke.
"Many overweight or obese individuals do not present the risks of metabolic diseases associated with a high BMI," explained Hanieh Yaghootkar of Exeter University in Britain.
"Meanwhile, some people with lean or normal weight develop diseases like type 2 diabetes," said Yaghootkar.
–IANS
pb / rt / gb / ksk
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