Keto diet: How the keto diet could improve the effectiveness of a new cancer drug



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NEW YORK: A ketogenic diet, low in carbohydrates and high in fat, could improve the effectiveness of a new class of cancer drugs, have discovered scientists, including an original Indian.

A study, published in the journal Nature, found a strategy to stimulate the tumor-killing potential of targeted therapies on the insulin-activated enzyme, phosphatidylinositol-3 kinase (PI3K) – a family of enzymes involved in cellular functions such as cell growth, proliferation and differentiation.

"Any drug that targets PI3K may not be effective unless patients can maintain low blood sugar levels through a diet or medication." We have shown that if we maintain insulin with the ketogenic diet, it significantly improves the effectiveness of these drugs. said Lewis C Cantley of Weill Cornell Medicine in the United States.

Some of the most common genetic mutations observed in cancerous tumors affect PI3K.

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<p>  The frequency of mutations in the gene has made it an attractive target for cancer drugs, and more than 20 therapies that inhibit the PI3K enzyme have entered clinical trials.
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<p>  However, the results of these tests have not been very promising.
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<p>  Some patients taking these drugs develop a hyperglycemia – excessively high blood sugar level – which is often temporary because the pancreas compensates by producing more insulin.
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<p>  The blood sugar levels of some patients do not return to normal and they must stop taking the drugs, according to the researchers.<br />
"This study represents a truly innovative approach to cancer. For decades, we have tried to alter human metabolism to make cancer cells more sensitive to chemotherapy or targeted drugs," said Siddhartha Mukherjee, an oncologist at Irving Medical Center. from Columbia University. in the USA.
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<p>  "The fact that this drug itself allows some kind of resistance – at least in animal models – is a total surprise, we are delighted to try this approach in humans," a- he said.
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