MRI to play a leading role in detecting signs of heart attack



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An Australian suffers a heart attack every 10 minutes, but this figure could change thanks to a breakthrough by a group of researchers in Sydney.

Scientists at the Victor Chang Institute discovered the dangerous plaque that accumulates Blood vessels leading to a heart attack contain a very active inflammatory enzyme.

This is a double discovery for scientists who also found a non-invasive MRI scanner that could be used to accurately detect the presence of problematic plaque.

  The researchers found the dangerous plaque that accumulates in the blood vessels causing a heart attack - contains a very active inflammatory enzyme. Photo: 9NEWS
Researchers have discovered the dangerous plaque that builds up in the blood vessels causing a heart attack – contains a very active inflammatory enzyme. Photo: 9NEWS

"Now, for the first time, once this is developed, we will be able to listen if you have a bad plaque and deal with it urgently," said Professor Bob Graham.

In tests on mice, the researchers found that when a chemical probe was injected into the blood, the plaque was easily visible, illuminating like a neon.

  They also discovered that a noninvasive MRI could detect the presence of this problematic plaque. Photo: 9NEWS
They also discovered that a noninvasive MRI can detect the presence of this problematic plaque. Picture: 9NEWS
  When a chemical probe is put into the bloodstream, the plate ignites. Picture: 9NEWS
When a chemical probe is put into the bloodstream, the plate lights up. Picture: 9NEWS

They also discovered that after using a drug to block enzymatic activity, the plaque stabilized, making the coronary artery wall more resistant and less likely to become to break up.

The early warning system could be the key to helping doctors diagnose those who are at risk of having a heart attack before it is too late.

The next step is to perform tests on humans, Sydney scientists preparing for clinical trials on a group of patients with a high-risk heart attack.

This should begin in two years

© Nine Digital Pty Ltd 2018

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