WASHINGTON D.C. [USA]: An anti-obesity drug derived from chili peppers caused long-term weight loss and improved metabolic health in mice eating a high-fat diet.
The study of the University of Wyoming's pharmacy school discovered that the new drug, Metabocin, was made from capsaicin, the compound that gives chili peppers their spicy burn.
It was designed to slowly release capsaicin throughout the day so that it can exert its anti-obesity effect without producing inflammation or unwanted side effects.
"We have seen marked improvements in blood sugar and cholesterol, insulin response, and symptoms of fatty liver," says lead researcher Dr. Baskaran Thyagarajan, describing how Metabocin reversed many of the adverse effects of high fat diet.
The research team developed Metabocin, which can be taken orally, to target receptors called TRPV1 (subfamily of potential transient receptor 1 vanilloid receptors) that are found in high numbers in cells fat. By stimulating TRPV1 receptors, white fat cells begin to burn energy instead of storing it, which in theory should lead to weight loss.