Weight loss: Trying to lose weight? New drug made from hot peppers can help



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WASHINGTON D.C. [USA]: An anti-obesity drug derived from chili peppers caused long-term weight loss and improved metabolic health in mice eating a high-fat diet.

The study of the University of Wyoming's pharmacy school discovered that the new drug, Metabocin, was made from capsaicin, the compound that gives chili peppers their spicy burn.

It was designed to slowly release capsaicin throughout the day so that it can exert its anti-obesity effect without producing inflammation or unwanted side effects.

"We have seen marked improvements in blood sugar and cholesterol, insulin response, and symptoms of fatty liver," says lead researcher Dr. Baskaran Thyagarajan, describing how Metabocin reversed many of the adverse effects of high fat diet.

The research team developed Metabocin, which can be taken orally, to target receptors called TRPV1 (subfamily of potential transient receptor 1 vanilloid receptors) that are found in high numbers in cells fat. By stimulating TRPV1 receptors, white fat cells begin to burn energy instead of storing it, which in theory should lead to weight loss.

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<p>  An important question for the researchers was whether the drug remains effective when it is used long-term, and if The adverse effects would outweigh its benefits.Mice in this experiment stayed on the drug for 8 months, maintaining weight loss without evidence of safety problems.Extra current experiments will see how long it can be maintained.
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<p>  "It was safe and was well tolerated by mice," Thyagarajan concluded. "The development of Metabocin as a potent anti-obesity treatment is promising as part of a strong strategy to help people struggling with obesity."
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<p>  Although these findings may give some people the idea of ​​eating more spicy foods to lose weight, it would not work as expected. Most of the capsaicin in spicy foods is not well absorbed into the body and therefore would not produce these effects. The researchers specifically modified capsaicin in Metabocin for adequate absorption and sustained release.
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<p>  The findings were presented at the 26th annual meeting of the Society for the Study of Ingestive Behavior.<br />
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Dietary foods contain fewer calories and are healthier alternatives to Conventional snacks such as potato chips, hamburgers and other fast food.

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