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The research team of Linköping University is already interested in the discomfort of pain and inflammation and in what makes us perceive pain as something negative. In their new study, mice lacking certain receptors in the brain – the melanocortin 4 receptors – react inversely to unpleasant things. The reward systems of these mice seem to be triggered by, for example, inflammation and nausea. They also did not perceive the pain as unpleasant.
– We saw that the mice were starting to behave strangely and were looking for something really bad for them, "says David Engblom, a professor in the Department of Clinical and Experimental Medicine. 39, expressing discomfort, but the animals begin to feel uncomfortable, it is very strange.
In most cases, the brains of humans and animals interpret certain feelings as positive and others as negative, it's about stepping us towards increasing our ability to survive and leading us from things that can hurt us.Why mice react as they do, they do not not know today, but the hope is that the study will continue research in the field of pain.
– Pain often has a warning purpose, "says David Engblom, but, for example, among people in p terminal hase of cancer, who often feel bad and have a lot of pain, it would be good to get rid of the discomfort. The same thing with people with chronic diseases.
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