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Mini-brains on which we can study the development of malignant tumors: Viennese researchers led by Jürgen Knoblich have made other breakthroughs.
17:53, 23 July 2018
Knoblich and the co-authors presented their findings in the scientific journal Nature Methods. The system should serve as a model for future research on brain tumors, he wrote
Limited possibilities in animal modeling
The antecedents are as follows: Models of brain tumors with genetically modified mice offer very limited possibilities because humans are different from mice in many ways. If one transfers tissue from human brain tumors to mice, one can no longer examine the origin of the tumors since the tumor tissue already exists.
In addition, the immune status of foreign tissue tolerant mice does not match that of humans. Finally, it is important to reproduce the tissue composition of the human brain in a three-dimensional way, which is hardly possible in the laboratory using other methods
Jürgen Knoblich is the only one of his kind. one of the most successful scientists in Austria. He conducts research at the Institute of Molecular Biotechnology (IMBA) of the Vienna Academy of Sciences
The brain organoids he and his team raised were named in 2013 as one of the world's best discoveries. l & # 39; year. These "mini-organs" are derived from human stem cells. Diseases can be studied on them
Detailed Brains
The Viennese scientists want to treat these problems with "neoplastic brain organoids". "These tiny organoids faithfully reproduce unique aspects of the human brain, such as its different cell types and developmental stages, allowing us to understand the development of tumors and provide a system for testing new therapies" Knoblich, Scientific Director acting at IMBA, was quoted as saying:
In the end, scientists have used several genetic modification techniques, such as methods for the propagation of oncogenes s DNA and the technique of "scissors" CRISPR-Cas9 to Organoids z Using data from the cancer genome reviews and using this information, it was possible to create brain organoids which correspond to glioblastomas or tumors of the central nervous system (CNS-PNET).
Scientists have called the system "NeoCOR".
Examine the origin of the disease
These models could now be used to study the development of tumor diseases in the brain in basic research. According to recent scientific research, diseases are probably several dozens of different diseases or subtypes. Old categorizations and characterizations could be obsolete. However, such 3D organoid models could also be used to test drugs for their potential effectiveness.
"The NeoCOR model is a valuable tool used to study the fundamentals of brain tumor biology and, worldwide, research is under way on various forms of cancer, such as the manufacture of test material derived from the tumor of individual patients to organoids of the affected organ, and then as quickly as possible can test the sensitivity to various drugs against cancer
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