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Medicine
Tuesday, July 31, 2018
/ Elroi, stock.adobe.com
London – In combination with chemotherapy, cannabidiol (CBD) may be beneficial in the treatment of pancreatic cancer. This is reported by researchers at Queen Mary University, London, and Curtin University, Australia, in Oncogene (2018, doi: 10.1038 / s41388-018-0390-1).
In a mouse study, CBD reported that survival almost doubled compared to mice treated with chemotherapy gemcitabine (GEM) alone (52.7 versus 27.8 days).
The cannabis plant Cannabis sativa contains more than 80 cannabinoids having the chemical structure of terpene phenols:
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- Tetrahydrocannabinol (THC)
- Cannabidiol (CBD)
- Cannabinol (CBN)
Unlike THC, CBD is not psychoactive. The CBD is not subject to the narcotics legislation
The study focused on G-protein coupled receptors (GPR55), which are thought to play a key role in the growth many cancers. However, the inhibition of the receptor could improve survival. CBD is the receptor antagonist.
"Cannabidiol is already approved for use in clinics, so we can test it quickly in human clinical trials," says Professor Marco Falasca, principal investigator at Queen Mary University in London. CBD is already known because it improves the side effects of chemotherapy, including nausea, diarrhea and vomiting. Thus, it would also improve the quality of life of patients undergoing chemotherapy
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