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"Unfortunately, it is common to see patients with breast cancer and prostate cancer patients whose tumor appears to have been defeated many years ago but whose bone metastasis returns ". Hofbauer, bone specialist at the Carl Gustav Carus University Hospital in Dresden and coordinator of the μBONE consortium. The result is a fracture, intense pain and a reduced quality of life. "Cancer cells in the human body in the bone marrow for years, a kind of" hibernation "and destroy after waking up the bone relatively quickly. Researchers want to understand the processes that lead to this development.
Why do cancer cells in the human body fall into this winter look? And what does it wake up for? Why do all breast and prostate cancer cells metastasize bones? Which communication channels favor the manipulation of bone cells in favor of tumor growth? And how do these cells hide from the human immune system? "The exact mechanisms and individual stages of bone and tumor cell development on the clinically recognizable bone metastasis pathway are insufficiently studied, but are a prerequisite for early diagnosis and improved prevention and treatment," explains Professor Lorenz Hofbauer . The goal is to better understand the development of bone metastases. "The coordination of the new 2084 priority program by the Dresden University Medical Center is another element of our efforts to further develop excellence in research and, at the same time, the recognition of our expertise. colleagues from all over Germany in the program of the German Foundation for Research strengthens our expertise in the field of cancer research in close relatives, "says Professor Michael Albrecht, Medical Director of the University Hospital Center.
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