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(NAPSI) – A migraine can be debilitating and sometimes hit like a runaway freight train, but did you know that in some cases it is preventable? Unfortunately, the preventive treatment of migraine is severely underused. Nearly 40% of migraine sufferers could benefit from preventive treatment, but only a small percentage benefits from this type of treatment.1
The prevention of migraine is only a conversation. Here is some information about migraine and preventive treatment options to help you talk to your doctor.
What are the causes of migraine and can it be prevented?
Just about everyone has a headache, but contrary to popular belief, migraine is not just a headache.2 In fact, the World Health Organization makes migraine one of the 10 most disabling diseases on the planet.3 Doctors do not know exactly what causes migraines, but they think that the imbalances of certain chemicals in the brain could play a role, as well as genetics and other factors, including:4
• physical and environmental elements. Emotional stress (one of the most common migraine triggers); consume salted processed foods, alcohol and caffeine; skip meals sensory overload; changes in the structure of sleep; physical effort; and changes in weather conditions.
• the genes. A family history of migraine increases the risk of migraine.
• age. Migraines can occur at any time in life, but the first usually occurs in adolescence. Migraines tend to reach their maximum in the thirties and are less severe later in life.
• Sex. Migraine is more common in women than in men.
• hormonal changes. Birth control pills and hormone replacement therapy can make migraine symptoms worse for some women but better for others.
Knowing your tendency to have a migraine and learning what to avoid, is a useful prevention technique. For people with frequent migraines who are not able to avoid or effectively treat a migraine after its onset, a migraine prevention therapy may be an answer.
What are the migraine prevention treatment options?
For patients with frequent migraine attacks (1 to 2 per week or more), doctors recommend preventive treatment.5 topiramate is the most commonly prescribed migraine preventative therapy because of a considerable body of evidence demonstrating its ability to improve outcomes in migraine patients in terms of disability reduction and improved quality of life.6 The American Academy of Neurology and the American Headache Society have given topiramate an "upscale" note for the prevention of migraine.7
The Food & Drug Administration (FDA) has approved Qudexy® XR (topiramate) extended-release capsules for the prevention of migraines in adults and adolescents 12 years of age and older. Qudexy XR is taken once a day orally.
In addition, three injectable anti-calcitonin Gene-related peptide therapies (CGRP), indicated for the preventive treatment of migraine in adults, have recently been approved by the FDA.
With all the available treatments for migraine prevention, it is important to talk to your doctor and consider options that can be tailored to your individual needs.
For more information on the prevention of migraine and Qudexy® XR, talk to your doctor or visit www.QudexyXR.com.
WHAT IMPORTANT INFORMATION ON SAFETY SHOULD I KNOW?
Qudexy® XR should not be used in patients with metabolic acidosis who are also taking a medication called metformin (for example., Glucophage®).
Qudexy XR can cause serious side effects, including:
• Serious eye problems, which may include blurred or sudden vision loss, eye pain and redness or fluid blockage that may cause increased eye pressure (secondary angle glaucoma). If left untreated, this can lead to permanent vision loss.
• Reduced perspiration and fever. People, especially children, should be monitored for signs of decreased sweating and fever, especially in hot weather. Some people may need to be hospitalized for this disease.
• Increased level of acid in the blood (metabolic acidosis). This may or may not cause symptoms. Symptoms may include feeling tired, loss of appetite, a change in heart rate, or difficulty thinking clearly. If it is not treated, metabolic acidosis can cause brittle or soft bones (osteoporosis, osteomalacia, l & # 39; osteopenia), kidney stones, can slow down the growth rate of children and possibly harm the fetus of pregnant women.
• High blood ammonia levels. High levels of ammonia in the blood can interfere with mental activity, slow alertness and cause fatigue or vomiting. It can also happen when Qudexy XR is taken with a medicine called valproic acid (for example, Depakene® and Depakote®).
• Kidney stones. Drink a lot of liquid while taking Qudexy XR to decrease your chances of getting kidney stones.
• Low body temperature. taking Qudexy XR when you also take valproic The acid can cause a drop in body temperature below 95 ° F, fatigue, confusion or coma.
• Effects on thought and alertness. Qudexy RX can affect the way you think and can cause confusion, problems with concentration, attention, memory or speech. Qudexy XR can cause depression or mood problems, fatigue and drowsiness.
• Dizziness or loss of muscle coordination.
Call your health care provider immediately if you have any of the above symptoms.
Like other antiepileptic drugs, Qudexy XR can cause suicidal thoughts or actions in a very small number of people, about 1 in 500 people. Before taking Qudexy XR, tell your health care provider if you have or have had depression, mood problems, thoughts or suicidal behavior. Call a health care provider immediately if you have thoughts about suicide or death; suicide attempt; have depression or new or worsening anxiety feel agitated or agitated have panic attacks, sleep disturbances (insomnia), new irritability or worsening; feel or act aggressively, angrily or violently; act on dangerous impulses; experience an extreme increase in physical activity and conversation (mania); or other unusual changes in your behavior or mood.
Qudexy XR can harm your unborn baby. All women of childbearing age should discuss alternative treatments with their health care provider. If you take Qudexy RX during pregnancy, your baby has a higher risk of congenital malformations called cleft lip and palate. These defects can begin early in pregnancy even before you know you are pregnant. Also, if you take Qudexy XR during pregnancy, your baby might be smaller than expected at birth; the long-term effects of this are not known. If the decision is made to use Qudexy XR, you must use effective contraception (contraception). Inform your health care provider immediately if you become pregnant or plan to become pregnant while taking Qudexy XR.
The most common side effects of Qudexy XR include: tingling of the arms and legs (paresthesia), not feeling hungry, weight loss, nervousness, nausea, slurred speech, tiredness, dizziness, drowsiness / drowsiness, change in food taste, upper respiratory tract infection, slow reactions, memory problems , fever, abnormal vision, diarrhea and pain in the abdomen. These are not all the possible side effects of Qudexy XR. For more information, ask your health care provider or pharmacist.
Before taking Qudexy XR, inform your health care provider of all your medical conditions, including if you: have had depression, mood problems, thoughts or suicidal behavior; have kidney problems, kidney stones or kidney dialysis have a history of metabolic acidosis (too much acid in the blood); have liver problems have brittle, brittle or soft bones (osteomalacia, osteoporosis, l & # 39; osteopenia, or decrease in bone density); have respiratory or pulmonary problems; have eye problems, especially glaucoma have diarrhea have a growth problem; are on a high fat and low carb diet, which is called a ketogenic diet; are operated on; Are pregnant or planning to become pregnant or if you are breast feeding. The drug in Qudexy XR (topiramate) passes into your breast milk. We do not know if the drug, topiramatepassing into breast milk can harm your baby. Talk to your health care provider about the best way to feed your baby if you take Qudexy XR.
Talk to your health care provider about all the medications you take, including prescription and over-the-counter medications, vitamins, and herbal supplements. Tell your health care provider if you are taking metformin (for example., Glucophage) valproic acid (for example, Depakene or Depakote) any medication that alters or diminishes your thinking, concentration or muscle coordination; contraceptive pills (Qudexy Radiation therapy may make the birth control pill less effective); medicines used to prevent epileptic seizures; or any other carbonic anhydrase inhibitors (for example, zonisamide, acetazolamide, or dichlorphenamide).
Do not stop Qudexy XR without first talking to a health care provider. If you suffer from epilepsy and stop taking Qudexy XR suddenly, you can have seizures that do not stop. Your health care provider will tell you how to stop taking Qudexy XR slowly.
Do not drink alcohol while taking Qudexy XR. Qudexy XR and alcohol can cause serious side effects such as drowsiness and severe dizziness, as well as an increase in seizures.
Do not drive, swim, ride or use heavy machinery until you know how Qudexy XR affects you. Qudexy XR may slow down your thinking and motor skills and may affect vision. Even taking Qudexy XR, some patients with epilepsy will continue to have unpredictable seizures.
QUDEXY XR, C & WH IS WHAT?
Qudexy® XR (topiramate) Extended release capsules are prescription drugs used:
• Prevent migraine headaches in adults and adolescents 12 years and older.
• treat certain types of seizures (partial seizures and generalized primitive tonicity)clonic convulsions) in adults and children 2 years and older.
• With other drugs to treat certain types of convulsions (partial trigger convulsions, generalized primary tonic treatment).clonic seizures and convulsions associated with Lennox-Gastaut syndrome) in adults and children 2 years and older.
This is the most important information to know about Qudexy XR, but is not complete. For more information, talk to your health care provider and read the Medication Guide for Qudexy XR. You can also visit www.upsher-smith.com or call 1-888-650-3789.
We encourage you to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Qudexy is a registered trademark of Upsher-Smith Laboratories, LLC.
All other trademarks are the property of their respective owners.
1. National Foundation of Headaches. Migraine prevention treatment: what's in the pipeline? Available at https://headaches.org/2017/03/13/migraine-preventive-therapy-whats-pipeline/. Accessed September 20, 2018.
2. Migraine Research Foundation. Available at https://migraineresearchfoundation.org/about-migraine/migraine-facts/. Accessed September 12, 2018.
3. American Migraine Foundation. Available at https://americanmigrainefoundation.org/living-with-migraine/. Accessed September 12, 2018.
4. WebMD. Available at https://www.webmd.com/head-heads/migraines-causes#1. Accessed September 12, 2018.
5. American Headache Society. Available at https://americanheadachesociety.org/wp-content/uploads/2018/05/Alan_Rapoport_-_Migraine_Prevention_Medications.pdf. Accessed September 12, 2018.
6. Silberstein SD. topiramate in the prevention of migraine: perspective 2016. Headache. January 201757(1): 165-178.
7. Silberstein SD, Holland S, Freitag F Dodick DW, Argoff C, Ashman E. Updated Evidence-Based Guidelines: Pharmacological Treatment for the Prevention of Episodic Migraine in Adults: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2012; 78 (17): 1337-1345.
On the net: North American Precis Syndicate, Inc. (NAPSI)
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