The next frontier for cannabis vapes: the mood-specific formulas



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As with any form of prohibition, once the door is open, there is an inevitable wave of overabundance. In recent years, we have witnessed the emergence of more and more powerful oils and concentrates. But as the smoke disappears, it changes. People explore various cocktails and new compounds in order to compose the effects to reach atmospheres and exact experiences. It can be as vague as "party" or as specific as to provoke lucid dreams. The problem is that we will probably only be able to do this in years (or decades). At least in a way that would be worthy of the FDA's stamp.

Vape pen filled with THC oil concentrate

Cannabis is a complex plant, that's what we know. "So, there are about 140, maybe a little more hydro-cannabinoids or cannabinoids derived from plants, THC and CBD being the two best studied, but there are still at least 130 more," says Piomelli , professor at the University of California at Irvine. President of his Center for the Study of Cannabis, in an interview with Engadget.

That's a lot of compounds in a plant that we do not know much about. But that does not stop people from trying. Strains that are raised in about 130 other cannabinoids are not common, but they should change in the future. In the meantime, cannabis companies are experimenting in three main ways: the THC / CBD ratio, with terpenes and other elements already present in the plant, and with additives other than cannabis.

Handling cannabis is not new. For decades, plants have been bred as dogs to improve their potency and effect. Whoever has watched Narcos: Mexico will know that even the famous "sensimilla" (essentially a "seedless" cannabis plant) is a byproduct of a human botanical intervention.

The number of gold

THC is, without a doubt, the star of the cannabis show. This is what has rocked humanity towards the factory. Its effects are undeniable and, for the most part, pleasant. The CBD is the next best known cannabinoid and is gaining ground, especially with the recent Farm Bill. It is the balance of these two compounds that gave the first clue that the effects of cannabis can be personalized.

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<p>"If you mix THC with something else, it will affect its actions," explained Piomelli. "CBD has a modulating property on what the THC does, and as a result, people are talking about the effect of the surrounding." This entourage effect is why you will see percentages or ratios of THC and CBD on the packaging of your vape cartridge. THC is the part that makes you climb, while the effects of CBD are less concrete. Generally, they are associated with calm, reduced anxiety or sleep (among so many others). The problem is that we know almost nothing about what different ratios could actually achieve, scientifically. Not least because everyone reacts differently.</p>
<p>According to Ray, experimentation is your best choice. "I think one of the challenges of cannabis and CBD is to adapt your personal formula," he said. "People still need to be crossed until they are able to find what is best for them." Fortunately, there are many products in a wide variety of reports and dosages for those who <i>make </i>want to experiment.</p>
<h3>Essentially oil</h3>
<p>Have any beer connoisseur describe his favorite IPA and you'll definitely hear about hops. In the world of weeds, it is the terpenes that give your hit its flavor and character. Some think that terpenes are also another way of composing our experience (in combination with the cannabinoid ratio).</p>
<p>The Californian company Dosist has the choice between six cannabis pens. Each "formula" is labeled with its main effect (Arouse, Calm, Bliss, etc.). Dosist sprays are for people looking for relief from pain or insomnia rather than those looking to bake. Along with the decomposition of THC / CBD ratios and complete terpene profiles (hand-picked), the pen vibrates once you have inhaled what Dosist considers to be the optimal amount (hence his name). The company's guidelines suggest a maximum of three "doses" per hour, barely enough to change your consciousness, but sufficient for the benefits – at least according to society.</p>
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Terpenes are essential oils found in many plants (not just cannabis). They have a characteristic smell and, for most people, this will largely define the taste of your cannabis vape. But some companies, like Dosist, believe that they can influence the power and direction of the effects of cannabis.

Piomelli is more skeptical. "I would say that 95% of claims are essentially unfounded Terpenes are compounds, they are biologically active compounds, and some terpenes are particularly active in the cannabinoid system," he says. "But the evidence that a combination of terpenes, so a specific terpene either improves, diminishes or otherwise alters the effects of THC, CBD and other cannabinoids, the evidence is not just not there. "

This does not mean that this idea has no merit, but simply that scientific evidence is scarce. "I am not the type to reject all the anecdotal evidence, if anecdotal evidence is made about thousands of people," added Piomelli. "There is a point where we have to ask ourselves if there is so much smoke that there must be fire."

Holistic summits

While cannabinoids and terpenes are promising, some people think that cannabis can help you get where you want to go. White Fox Atmospheres is part of the growing number of brands that add other herbs to the mix. The company's website defines its mission as "formulating, alchimizing and creating a specific effect medicine".

White Fox vape products contain good old cannabis, but with "Ayurvedic formulations" added. Ayurvedic medicine is where things go even further in the unknown. The formulations date back several millennia but also lack definitive scientific research on their medical efficacy.

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<p>Scarlet Ravin, founder and CEO of White Fox, creates this line for the sole purpose of helping people feel better. Tired of the arms race in cannabis, the zero-sum game that involves reaching incredibly high levels, she tells Engadget that she wants to answer the question "How can we use drugs effectively, while we do not just become super stoned and blowing our heads? "</p>
<p>The result is three different cannabis vape formulas: one for masculine and feminine sexual energy and another that promises to enhance your ability to achieve lucid dreams. Ravine is aware that a product called "legendary" or something containing valeriana root wallichii may raise some expectations, but he claims that, like most holistic remedies, the effect obtained can be more, better holistic.</p>
<p>"So our formula somehow puts people back into this state of inner balance," she says, "and many of those who smoke pens smoke regularly, will say," I got it for it would hurt me to see if it would work and I felt like I was back in my body and felt like I was in my heart when I smoke this pen. & # 39; So, it's more of a state of general well-being than an atmosphere, you know? "</p>
<h3>What about research?</h3>
<p>The search for new specific effects of cannabis is not surprising. Piomelli explains that cannabinoids have what is called a "privileged structure". This means that they are more likely to have a physiological or pharmacological effect.</p>
<p>Understanding the ratios, terpenes and interactions between cannabinoids is the key to a personalized cannabis future. A future in perhaps a few years, according to Jacob Borodovsky, a researcher in the Department of Psychiatry at the University of Washington School of Medicine, specializing in the epidemiology of cannabis and opioids. "I think we'll come to such a place after you and I have been dead for a long time," he says. "I think it will go first through medicine through neurobiology, and we will begin to understand these things a lot better."</p>
<p>Borodovsky refers, in part, to the slowness with which science can study such things. The number of studies needed is important – far more than the financial resources available to carry them out. Cannabis is now a commercial enterprise and it is difficult to patent nature. Piomelli agrees: "It will cost many millions of dollars because you need a lot of subjects and placebo controls. This is an expensive undertaking and no company is interested in doing it because how would they protect their property? "</p>
<p>From time to time, however, we have enough evidence to turn a medicine into a cure. Epidiolex is a recently approved CBD-based drug for the treatment of Dravet syndrome (a serious form of epilepsy in infants).</p>
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But why wait for science to catch up? Humans have experimented with all kinds of substances themselves for millennia. The Bloom Farms department takes a properly measured approach with its products. "I've always been convinced that it's better to stay as faithful to the plant as possible," he said, referring to the current wave of CBD-based products in Canada. booming. Some are pure extracts, while others, like Bloom Farms, are "full spectrum", which means they contain traces of other natural cannabinoids. The theory being, like your olive oil, the magic lies in the plant, not just in the desired compound.

Likewise, Ravin is confident that she is on something. "When I'm at a clinic and doing a demonstration day, I feel a little ahead of my time compared to what we offer," she says. "But it's just now that we're starting to understand that a sufficient number of people have smoked it and said:" I really like that. " can not say exactly why, but I like what I feel when I'm on it and I want to keep feeling that "

The rush for new products does not seem to be slowing down anytime soon. Legalization is perhaps the most powerful ingredient in the development of cannabis. No longer afraid of prosecution, scientists can explore more freely and consumers can experience what suits them best. Now, clinics like Sava offer education alongside these a la carte products (and even home delivery): getting the desired craze has never been easier.

Just like your favorite vacation destination, or your choice of coffee, your personal endorsement is finally king. We all know what alcohol makes us a little emotional or relieves a hard day at work. Even Piomelli admits that if it works for you and is not harmful, it's worth taking into consideration. "It's a personal matter," he says. "Personal taste, I do not drink white wine because it gives me a headache, I do not think it justifies a clinical trial."

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